抗人 SCRIB 抗体对
01AB03014
(SCRIB) is a large LAP family scaffold protein that localizes to basolateral cell-cell junctions to organize multiprotein complexes controlling cell polarity, adhesion, and signaling. It contains multiple leucine-rich repeats and four PDZ domains that facilitate interactions with diverse partners, including beta-catenin, beta-PIX, and GIT1. Through the Scribble module, it coordinates actin dynamics and vesicle trafficking while antagonizing apical Par and Crumbs complexes to maintain basolateral identity. SCRIB is essential for regulating tissue growth and directed cell migration. Clinically, SCRIB functions as a context-dependent tumor suppressor, and its mislocalization or reduced expression is frequently linked to breast and other epithelial cancers. Additionally, perturbations in SCRIB are associated with developmental defects, particularly in neural tube formation, highlighting its fundamental role in establishing and maintaining structural organization in tissues.
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技术参数
- 靶点基因名
- SCRIB
- 基因别名
- CRIB1; KIAA0147; LAP4; SCRB1; VARTUL
- 蛋白别名
- Protein scribble homolog (Scribble) (hScrib) (Protein LAP4); SCRIB
- UniProt
- Q14160
- 物种
- Human
产品详情
- 靶点名称
- SCRIB
- 蛋白名称
- Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
- 蛋白别名
- Protein scribble homolog; Scribble; hScrib; Protein LAP4
- 靶点基因名
- SCRIB
- 基因别名
- CRIB1; KIAA0147; LAP4; SCRB1; VARTUL
- UniProt
- Q14160
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
(SCRIB) is a large LAP family scaffold protein that localizes to basolateral cell-cell junctions to organize multiprotein complexes controlling cell polarity, adhesion, and signaling. It contains multiple leucine-rich repeats and four PDZ domains that facilitate interactions with diverse partners, including beta-catenin, beta-PIX, and GIT1. Through the Scribble module, it coordinates actin dynamics and vesicle trafficking while antagonizing apical Par and Crumbs complexes to maintain basolateral identity. SCRIB is essential for regulating tissue growth and directed cell migration. Clinically, SCRIB functions as a context-dependent tumor suppressor, and its mislocalization or reduced expression is frequently linked to breast and other epithelial cancers. Additionally, perturbations in SCRIB are associated with developmental defects, particularly in neural tube formation, highlighting its fundamental role in establishing and maintaining structural organization in tissues.