人 SCGN 抗体对
01AB03420
Secretagogin, EF-hand calcium binding protein (SCGN) is a specialized calcium sensor composed of six EF-hand motifs arranged in three paired domains. Upon binding four calcium ions, the protein undergoes significant conformational changes that expose hydrophobic residues, distinguishing it as a sensor rather than a buffer. Highly expressed in pancreatic islet and neuroendocrine cells, SCGN interacts specifically with SNAP-25 to regulate calcium-induced exocytosis and secretory granule trafficking. This selective interaction differentiates it from more promiscuous sensors like calmodulin, positioning it as a key regulator of neuronal and endocrine secretion. Clinically, SCGN is a recognized biomarker for neuroendocrine tumors, including insulinomas and carcinoid tumors of the lung and gastrointestinal tract. It is also involved in regulating cell proliferation and apoptosis, making it a valuable tool for identifying specialized secretory cell types and their associated malignancies.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- SCGN
- 基因别名
- SECRET
- 蛋白别名
- secretagogin, EF-hand calcium binding protein; SCGN
- UniProt
- O76038
- 物种
- Human
产品详情
- 靶点名称
- SCGN
- 蛋白名称
- secretagogin, EF-hand calcium binding protein
- 蛋白别名
- Secretagogin
- 靶点基因名
- SCGN
- 基因别名
- SECRET
- UniProt
- O76038
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Secretagogin, EF-hand calcium binding protein (SCGN) is a specialized calcium sensor composed of six EF-hand motifs arranged in three paired domains. Upon binding four calcium ions, the protein undergoes significant conformational changes that expose hydrophobic residues, distinguishing it as a sensor rather than a buffer. Highly expressed in pancreatic islet and neuroendocrine cells, SCGN interacts specifically with SNAP-25 to regulate calcium-induced exocytosis and secretory granule trafficking. This selective interaction differentiates it from more promiscuous sensors like calmodulin, positioning it as a key regulator of neuronal and endocrine secretion. Clinically, SCGN is a recognized biomarker for neuroendocrine tumors, including insulinomas and carcinoid tumors of the lung and gastrointestinal tract. It is also involved in regulating cell proliferation and apoptosis, making it a valuable tool for identifying specialized secretory cell types and their associated malignancies.