人 SCGB3A2 抗体对
01AB01832
Secretoglobin family 3A member 2 (SCGB3A2) is a secreted lung surfactant and cytokine-like protein primarily expressed in airway club cells under the regulation of thyroid transcription factor-1. It functions as a critical modulator of respiratory homeostasis by binding the scavenger receptor MARCO and inhibiting secreted phospholipase A2 (PLA2G1B), which mediates its potent anti-inflammatory and anti-fibrotic effects. During development, SCGB3A2 promotes branching morphogenesis and maturation of the fetal lung. It also interacts with microbial pathogens and may influence pituitary hormone production. Clinically, SCGB3A2 is associated with susceptibility to asthma and interstitial lung disease, where its downregulation or genetic polymorphism contributes to chronic airway inflammation. Recombinant SCGB3A2 has shown potential in suppressing allergic airway responses, highlighting its protective role in the respiratory epithelium.
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技术参数
- 靶点基因名
- SCGB3A2
- 基因别名
- PNSP1; UGRP1
- 蛋白别名
- secretoglobin family 3A member 2; SCGB3A2
- UniProt
- Q96PL1
- 物种
- Human
产品详情
- 靶点名称
- SCGB3A2
- 蛋白名称
- secretoglobin family 3A member 2
- 蛋白别名
- Secretoglobin family 3A member 2; Pneumo secretory protein 1; PnSP-1; Uteroglobin-related protein 1
- 靶点基因名
- SCGB3A2
- 基因别名
- PNSP1; UGRP1
- UniProt
- Q96PL1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Secretoglobin family 3A member 2 (SCGB3A2) is a secreted lung surfactant and cytokine-like protein primarily expressed in airway club cells under the regulation of thyroid transcription factor-1. It functions as a critical modulator of respiratory homeostasis by binding the scavenger receptor MARCO and inhibiting secreted phospholipase A2 (PLA2G1B), which mediates its potent anti-inflammatory and anti-fibrotic effects. During development, SCGB3A2 promotes branching morphogenesis and maturation of the fetal lung. It also interacts with microbial pathogens and may influence pituitary hormone production. Clinically, SCGB3A2 is associated with susceptibility to asthma and interstitial lung disease, where its downregulation or genetic polymorphism contributes to chronic airway inflammation. Recombinant SCGB3A2 has shown potential in suppressing allergic airway responses, highlighting its protective role in the respiratory epithelium.