抗人 SCARA5 抗体对
01AB01336
Scavenger receptor class A member 5 (SCARA5) is a cell surface protein. It forms a disulfide-linked homotrimer exceeding 250 kDa and is primarily expressed in testicular Sertoli and germ cells, with weaker expression in other epithelial tissues. Functionally, SCARA5 acts as a ferritin receptor mediating non-transferrin-dependent iron delivery by stimulating ferritin endocytosis, thus playing a critical role in intracellular iron homeostasis. It also binds bacterial particles but not yeast or modified LDL. SCARA5 is a positive regulator of adipocyte lineage commitment and early adipogenesis in mesenchymal stem cells, modulating differentiation through the FAK-ERK signaling pathway and glucocorticoid-induced expression. In disease contexts, SCARA5 suppresses proliferation and migration and promotes apoptosis in human retinoblastoma cells by inhibiting the PI3K/AKT pathway, suggesting a tumor suppressor role. Its dysregulation may impact cancer progression and metabolic disorders linked to iron metabolism and adipogenesis.
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技术参数
- 靶点基因名
- SCARA5
- 蛋白别名
- scavenger receptor class A member 5; SCARA5
- UniProt
- Q6ZMJ2
- 物种
- Human
产品详情
- 靶点名称
- SCARA5
- 蛋白名称
- scavenger receptor class A member 5
- 蛋白别名
- Scavenger receptor class A member 5; Scavenger receptor hlg
- 靶点基因名
- SCARA5
- UniProt
- Q6ZMJ2
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Scavenger receptor class A member 5 (SCARA5) is a cell surface protein. It forms a disulfide-linked homotrimer exceeding 250 kDa and is primarily expressed in testicular Sertoli and germ cells, with weaker expression in other epithelial tissues. Functionally, SCARA5 acts as a ferritin receptor mediating non-transferrin-dependent iron delivery by stimulating ferritin endocytosis, thus playing a critical role in intracellular iron homeostasis. It also binds bacterial particles but not yeast or modified LDL. SCARA5 is a positive regulator of adipocyte lineage commitment and early adipogenesis in mesenchymal stem cells, modulating differentiation through the FAK-ERK signaling pathway and glucocorticoid-induced expression. In disease contexts, SCARA5 suppresses proliferation and migration and promotes apoptosis in human retinoblastoma cells by inhibiting the PI3K/AKT pathway, suggesting a tumor suppressor role. Its dysregulation may impact cancer progression and metabolic disorders linked to iron metabolism and adipogenesis.