抗人 SATB2 抗体对
01AB01329
SATB homeobox 2 (SATB2) is a DNA-binding protein that specifically binds to nuclear matrix attachment regions and plays a crucial role in transcriptional regulation and chromatin remodeling. It contains two CUT domains and a homeodomain, and is highly conserved across species. SATB2 is involved in various developmental processes, including craniofacial patterning, osteoblast differentiation, and cortical neuron differentiation. It functions by organizing chromatin structure and coordinating the activity of multiple genes. SATB2 is expressed in specific tissues, particularly in the nuclei of neurons in the brain and epithelial cells of the colon and rectum. Mutations in the SATB2 gene are associated with SATB2-associated syndrome, characterized by intellectual disability, severe speech problems, dental abnormalities, and craniofacial anomalies. The syndrome can also include behavioral issues and developmental delays. Also, SATB2 has been implicated as a potential biomarker for colorectal cancer.
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技术参数
- 靶点基因名
- SATB2
- 基因别名
- KIAA1034
- 蛋白别名
- SATB homeobox 2; SATB2
- UniProt
- Q9UPW6
- 物种
- Human
产品详情
- 靶点名称
- SATB2
- 蛋白名称
- SATB homeobox 2
- 蛋白别名
- DNA-binding protein SATB2; Special AT-rich sequence-binding protein 2
- 靶点基因名
- SATB2
- 基因别名
- KIAA1034
- UniProt
- Q9UPW6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
SATB homeobox 2 (SATB2) is a DNA-binding protein that specifically binds to nuclear matrix attachment regions and plays a crucial role in transcriptional regulation and chromatin remodeling. It contains two CUT domains and a homeodomain, and is highly conserved across species. SATB2 is involved in various developmental processes, including craniofacial patterning, osteoblast differentiation, and cortical neuron differentiation. It functions by organizing chromatin structure and coordinating the activity of multiple genes. SATB2 is expressed in specific tissues, particularly in the nuclei of neurons in the brain and epithelial cells of the colon and rectum. Mutations in the SATB2 gene are associated with SATB2-associated syndrome, characterized by intellectual disability, severe speech problems, dental abnormalities, and craniofacial anomalies. The syndrome can also include behavioral issues and developmental delays. Also, SATB2 has been implicated as a potential biomarker for colorectal cancer.