人 S6K1 抗体对
01AB02275
Ribosomal protein S6 kinase B1 (S6K1) is a cytoplasmic serine/threonine kinase of the AGC family that serves as a primary downstream effector of the mTORC1 signaling pathway. Activated by growth factors and nutrients through multisite phosphorylation by mTORC1 and PDK1, S6K1 promotes mRNA translation, cell growth, and proliferation by phosphorylating key substrates including ribosomal protein S6, eIF4B, and SKAR. It also mediates negative feedback to insulin and PI3K signaling via phosphorylation of IRS1. Dysregulated S6K1 activity is strongly implicated in metabolic disorders, such as insulin resistance, obesity, and type 2 diabetes. Furthermore, amplification and overexpression of the RPS6KB1 gene are frequently observed in various malignancies, particularly breast cancer, where it drives aberrant cell survival and growth.
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技术参数
- 靶点基因名
- RPS6KB1
- 基因别名
- STK14A
- 蛋白别名
- ribosomal protein S6 kinase B1; S6K1
- UniProt
- P23443
- 物种
- Human
产品详情
- 靶点名称
- S6K1
- 蛋白名称
- ribosomal protein S6 kinase B1
- 蛋白别名
- Ribosomal protein S6 kinase beta-1; S6K-beta-1; S6K1; 70 kDa ribosomal protein S6 kinase 1; P70S6K1; p70-S6K 1; Ribosomal protein S6 kinase I; Serine/threonine-protein kinase 14A; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA
- 靶点基因名
- RPS6KB1
- 基因别名
- STK14A
- UniProt
- P23443
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ribosomal protein S6 kinase B1 (S6K1) is a cytoplasmic serine/threonine kinase of the AGC family that serves as a primary downstream effector of the mTORC1 signaling pathway. Activated by growth factors and nutrients through multisite phosphorylation by mTORC1 and PDK1, S6K1 promotes mRNA translation, cell growth, and proliferation by phosphorylating key substrates including ribosomal protein S6, eIF4B, and SKAR. It also mediates negative feedback to insulin and PI3K signaling via phosphorylation of IRS1. Dysregulated S6K1 activity is strongly implicated in metabolic disorders, such as insulin resistance, obesity, and type 2 diabetes. Furthermore, amplification and overexpression of the RPS6KB1 gene are frequently observed in various malignancies, particularly breast cancer, where it drives aberrant cell survival and growth.