抗人 S100B 抗体对
01AB03328
S100B is a calcium-binding protein that is primarily found in astrocytes in the nervous system. It has been implicated in a variety of neurological and psychiatric disorders. S100B has both neurotrophic and apoptotic effects, depending on its extracellular concentration. At low concentrations, S100B can have beneficial effects, such as improving redox state, suppressing neuroinflammation, and enhancing nerve impulse transmission. However, at higher concentrations, S100B can stimulate the caspase pathway, leading to increased production of reactive oxygen species and cytotoxicity. This dual role of S100B has led to the hypothesis that its dysregulation may contribute to the pathogenesis of various neurological disorders, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury. Elevated levels of S100B have been observed in the serum and cerebrospinal fluid of patients with these conditions, making it a potential biomarker for disease severity, progression, and response to treatment.
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技术参数
- 靶点基因名
- S100B
- 蛋白别名
- S100 calcium binding protein B; S100B
- UniProt
- P04271
- 物种
- Human
产品详情
- 靶点名称
- S100B
- 蛋白名称
- S100 calcium binding protein B
- 蛋白别名
- Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B
- 靶点基因名
- S100B
- UniProt
- P04271
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
S100B is a calcium-binding protein that is primarily found in astrocytes in the nervous system. It has been implicated in a variety of neurological and psychiatric disorders. S100B has both neurotrophic and apoptotic effects, depending on its extracellular concentration. At low concentrations, S100B can have beneficial effects, such as improving redox state, suppressing neuroinflammation, and enhancing nerve impulse transmission. However, at higher concentrations, S100B can stimulate the caspase pathway, leading to increased production of reactive oxygen species and cytotoxicity. This dual role of S100B has led to the hypothesis that its dysregulation may contribute to the pathogenesis of various neurological disorders, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury. Elevated levels of S100B have been observed in the serum and cerebrospinal fluid of patients with these conditions, making it a potential biomarker for disease severity, progression, and response to treatment.