抗人 S100A4 抗体对
01AB00927
S100 calcium binding protein A4 (S100A4) is a calcium-binding protein that plays diverse roles in cellular processes including motility, angiogenesis, differentiation, apoptosis, and autophagy. It functions both intracellularly and extracellularly, interacting with various target proteins upon calcium binding. Intracellularly, S100A4 promotes cell migration by interacting with cytoskeletal components like myosin. Extracellularly, it acts as a signaling molecule, stimulating cytokine production and chemotaxis. S100A4 is involved in multiple pathological processes, particularly cancer metastasis, where its overexpression correlates with poor prognosis in various tumor types. It promotes metastasis by enhancing cell motility, invasion, and angiogenesis. Additionally, S100A4 has been implicated in inflammatory and fibrotic conditions affecting multiple organs. In the nervous system, S100A4 contributes to neurogenesis, cellular motility, and may play a role in neurological disorders such as brain tumors and neurodegenerative diseases.
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技术参数
- 靶点基因名
- S100A4
- 基因别名
- CAPL; MTS1
- 蛋白别名
- S100 calcium binding protein A4; S100A4
- UniProt
- P26447
- 物种
- Human
产品详情
- 靶点名称
- S100A4
- 蛋白名称
- S100 calcium binding protein A4
- 蛋白别名
- Protein S100-A4; Calvasculin; Metastasin; Placental calcium-binding protein; Protein Mts1; S100 calcium-binding protein A4
- 靶点基因名
- S100A4
- 基因别名
- CAPL; MTS1
- UniProt
- P26447
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
S100 calcium binding protein A4 (S100A4) is a calcium-binding protein that plays diverse roles in cellular processes including motility, angiogenesis, differentiation, apoptosis, and autophagy. It functions both intracellularly and extracellularly, interacting with various target proteins upon calcium binding. Intracellularly, S100A4 promotes cell migration by interacting with cytoskeletal components like myosin. Extracellularly, it acts as a signaling molecule, stimulating cytokine production and chemotaxis. S100A4 is involved in multiple pathological processes, particularly cancer metastasis, where its overexpression correlates with poor prognosis in various tumor types. It promotes metastasis by enhancing cell motility, invasion, and angiogenesis. Additionally, S100A4 has been implicated in inflammatory and fibrotic conditions affecting multiple organs. In the nervous system, S100A4 contributes to neurogenesis, cellular motility, and may play a role in neurological disorders such as brain tumors and neurodegenerative diseases.