人 S100A13 抗体对
01AB03416
S100 calcium binding protein A13 (S100A13) is a member of the S100 family of calcium-binding proteins, characterized by two EF-hand motifs and unique amphiphilic alpha-helices. It is widely expressed across various tissues, with particularly high levels in the thyroid gland. S100A13 plays a specialized role in the alternative secretory pathway, where it facilitates the export of proteins lacking a signal peptide, such as interleukins and fibroblast growth factors. This process is dependent on its ability to bind both calcium and copper ions. Intracellularly, S100A13 localizes to the nucleus and stress fibers, where it regulates cell cycle progression, differentiation, and motility. Clinically, S100A13 is recognized as a novel marker for angiogenesis and is associated with the progression of lung cancer and trachea leiomyoma. Its essential role in the stress-induced secretion of pro-angiogenic and pro-inflammatory factors underscores its significance in tissue remodeling and tumor microenvironment dynamics.
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技术参数
- 靶点基因名
- S100A13
- 蛋白别名
- S100 calcium binding protein A13; S100A13
- UniProt
- Q99584
- 物种
- Human
产品详情
- 靶点名称
- S100A13
- 蛋白名称
- S100 calcium binding protein A13
- 蛋白别名
- Protein S100-A13; S100 calcium-binding protein A13
- 靶点基因名
- S100A13
- UniProt
- Q99584
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
S100 calcium binding protein A13 (S100A13) is a member of the S100 family of calcium-binding proteins, characterized by two EF-hand motifs and unique amphiphilic alpha-helices. It is widely expressed across various tissues, with particularly high levels in the thyroid gland. S100A13 plays a specialized role in the alternative secretory pathway, where it facilitates the export of proteins lacking a signal peptide, such as interleukins and fibroblast growth factors. This process is dependent on its ability to bind both calcium and copper ions. Intracellularly, S100A13 localizes to the nucleus and stress fibers, where it regulates cell cycle progression, differentiation, and motility. Clinically, S100A13 is recognized as a novel marker for angiogenesis and is associated with the progression of lung cancer and trachea leiomyoma. Its essential role in the stress-induced secretion of pro-angiogenic and pro-inflammatory factors underscores its significance in tissue remodeling and tumor microenvironment dynamics.