人 S100 alpha9 抗体对
01AB02923
S100 calcium binding protein A9 (S100 alpha9), or MRP14, is a pro-inflammatory protein of the S100 family predominantly expressed in neutrophils and monocytes. It frequently heterodimerizes with S100A8 to form calprotectin, playing key roles in cytoskeletal dynamics and arachidonic acid metabolism. Extracellularly, S100A9 acts as a danger-associated molecular pattern (DAMP), binding TLR4 and RAGE receptors to activate NF-κB signaling and amplify immune responses. It also exhibits antimicrobial properties via metal sequestration. Elevated S100A9 levels are a hallmark of chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease, and contribute to tumor progression by fostering an immunosuppressive microenvironment.
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技术参数
- 靶点基因名
- S100A9
- 基因别名
- CAGB; CFAG; MRP14
- 蛋白别名
- S100 calcium binding protein A9; S100 alpha9
- UniProt
- P06702
- 物种
- Human
产品详情
- 靶点名称
- S100 alpha9
- 蛋白名称
- S100 calcium binding protein A9
- 蛋白别名
- Protein S100-A9; Calgranulin-B; Calprotectin L1H subunit; Leukocyte L1 complex heavy chain; Migration inhibitory factor-related protein 14; MRP-14; p14; S100 calcium-binding protein A9
- 靶点基因名
- S100A9
- 基因别名
- CAGB; CFAG; MRP14
- UniProt
- P06702
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
S100 calcium binding protein A9 (S100 alpha9), or MRP14, is a pro-inflammatory protein of the S100 family predominantly expressed in neutrophils and monocytes. It frequently heterodimerizes with S100A8 to form calprotectin, playing key roles in cytoskeletal dynamics and arachidonic acid metabolism. Extracellularly, S100A9 acts as a danger-associated molecular pattern (DAMP), binding TLR4 and RAGE receptors to activate NF-κB signaling and amplify immune responses. It also exhibits antimicrobial properties via metal sequestration. Elevated S100A9 levels are a hallmark of chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease, and contribute to tumor progression by fostering an immunosuppressive microenvironment.