人 RSPO3 抗体对
01AB00389
R-spondin 3 (RSPO3) is a protein encoded by the RSPO3 gene in humans, belonging to the thrombospondin type 1 repeat gene superfamily. It contains a furin-like cysteine-rich region and plays a crucial role in signal transduction by receptor tyrosine kinases. RSPO3 is a potent enhancer of Wnt signaling, particularly in the stem cell niche, where it regulates stem cell expansion and differentiation. Disruption of its niche-confined expression can lead to disturbances in tissue organization and potentially to cancers. RSPO3 has been implicated in the regulation of radioresistance in non-small cell lung cancer cells via NLRP3 inflammasome-mediated pyroptosis. Additionally, its overexpression has been associated with hematologic toxicities, including anemia and lymphopenia.
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技术参数
- 靶点基因名
- RSPO3
- 基因别名
- PWTSR; THSD2
- 蛋白别名
- R-spondin 3; RSPO3
- UniProt
- Q9BXY4
- 物种
- Human
产品详情
- 靶点名称
- RSPO3
- 蛋白名称
- R-spondin 3
- 蛋白别名
- R-spondin-3; Protein with TSP type-1 repeat; hPWTSR; Roof plate-specific spondin-3; hRspo3; Thrombospondin type-1 domain-containing protein 2
- 靶点基因名
- RSPO3
- 基因别名
- PWTSR; THSD2
- UniProt
- Q9BXY4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
R-spondin 3 (RSPO3) is a protein encoded by the RSPO3 gene in humans, belonging to the thrombospondin type 1 repeat gene superfamily. It contains a furin-like cysteine-rich region and plays a crucial role in signal transduction by receptor tyrosine kinases. RSPO3 is a potent enhancer of Wnt signaling, particularly in the stem cell niche, where it regulates stem cell expansion and differentiation. Disruption of its niche-confined expression can lead to disturbances in tissue organization and potentially to cancers. RSPO3 has been implicated in the regulation of radioresistance in non-small cell lung cancer cells via NLRP3 inflammasome-mediated pyroptosis. Additionally, its overexpression has been associated with hematologic toxicities, including anemia and lymphopenia.