人 RSPO1 抗体对
01AB00387
R-spondin 1 (RSPO1) is a secreted glycoprotein that plays a critical role in the regulation of the Wnt signaling pathway, particularly by acting as a ligand for the LGR4, LGR5, and LGR6 receptors. This interaction enhances Wnt/β-catenin signaling, which is essential for stem cell maintenance and proliferation across various tissues, including the ovaries and intestines. RSPO1 is structurally characterized by two cysteine-rich furin-like domains and a thrombospondin type 1 domain, which facilitate its binding to both LGR receptors and negative regulators of Wnt signaling like ZNRF3. Dysregulation or mutations in RSPO1 are associated with several diseases, most notably ovarian cancer, where it promotes tumorigenesis by activating Wnt/β-catenin signaling pathways. Additionally, genetic mutations in RSPO1 can lead to developmental disorders such as female-to-male sex reversal in XX individuals and are implicated in various cancers due to their roles in cell proliferation and differentiation.
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技术参数
- 靶点基因名
- RSPO1
- 蛋白别名
- R-spondin 1; RSPO1
- UniProt
- Q2MKA7
- 物种
- Human
产品详情
- 靶点名称
- RSPO1
- 蛋白名称
- R-spondin 1
- 蛋白别名
- R-spondin-1; Roof plate-specific spondin-1; hRspo1
- 靶点基因名
- RSPO1
- UniProt
- Q2MKA7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
R-spondin 1 (RSPO1) is a secreted glycoprotein that plays a critical role in the regulation of the Wnt signaling pathway, particularly by acting as a ligand for the LGR4, LGR5, and LGR6 receptors. This interaction enhances Wnt/β-catenin signaling, which is essential for stem cell maintenance and proliferation across various tissues, including the ovaries and intestines. RSPO1 is structurally characterized by two cysteine-rich furin-like domains and a thrombospondin type 1 domain, which facilitate its binding to both LGR receptors and negative regulators of Wnt signaling like ZNRF3. Dysregulation or mutations in RSPO1 are associated with several diseases, most notably ovarian cancer, where it promotes tumorigenesis by activating Wnt/β-catenin signaling pathways. Additionally, genetic mutations in RSPO1 can lead to developmental disorders such as female-to-male sex reversal in XX individuals and are implicated in various cancers due to their roles in cell proliferation and differentiation.