抗人 RSPH1 抗体对
01AB00923
Radial spoke head component 1 (RSPH1) is a key structural protein found in the axonemal radial spoke complexes of motile cilia and flagella, where it plays a crucial role in regulating ciliary and flagellar motility by contributing to the assembly and stability of the radial spoke head structure. RSPH1 is characterized by multiple membrane occupation and recognition nexus (MORN) repeats, forming elongated curved beta-sheets that interact with other radial spoke proteins through hydrogen bonds, hydrophobic, and electrostatic interactions, thereby locking the core of the radial spoke head in place and extending its surface for optimal function. The protein is predominantly expressed in tissues with motile cilia or flagella, such as the respiratory tract and sperm, and is essential for proper ciliary movement. Mutations in RSPH1 are associated with primary ciliary dyskinesia, a disorder marked by impaired ciliary motility leading to chronic respiratory infections and reduced fertility due to defective sperm flagella.
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技术参数
- 靶点基因名
- RSPH1
- 基因别名
- TSA2; TSGA2
- 蛋白别名
- radial spoke head component 1; RSPH1
- UniProt
- Q8WYR4
- 物种
- Human
产品详情
- 靶点名称
- RSPH1
- 蛋白名称
- radial spoke head component 1
- 蛋白别名
- Radial spoke head 1 homolog; Cancer/testis antigen 79; CT79; Male meiotic metaphase chromosome-associated acidic protein; Meichroacidin; Testis-specific gene A2 protein
- 靶点基因名
- RSPH1
- 基因别名
- TSA2; TSGA2
- UniProt
- Q8WYR4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Radial spoke head component 1 (RSPH1) is a key structural protein found in the axonemal radial spoke complexes of motile cilia and flagella, where it plays a crucial role in regulating ciliary and flagellar motility by contributing to the assembly and stability of the radial spoke head structure. RSPH1 is characterized by multiple membrane occupation and recognition nexus (MORN) repeats, forming elongated curved beta-sheets that interact with other radial spoke proteins through hydrogen bonds, hydrophobic, and electrostatic interactions, thereby locking the core of the radial spoke head in place and extending its surface for optimal function. The protein is predominantly expressed in tissues with motile cilia or flagella, such as the respiratory tract and sperm, and is essential for proper ciliary movement. Mutations in RSPH1 are associated with primary ciliary dyskinesia, a disorder marked by impaired ciliary motility leading to chronic respiratory infections and reduced fertility due to defective sperm flagella.