抗人 RRM2B 抗体对
01AB00919
Ribonucleotide reductase regulatory TP53 inducible subunit M2B (RRM2B) is a critical component of the ribonucleotide reductase enzyme, which catalyzes the conversion of ribonucleotides to deoxyribonucleotides for DNA synthesis and repair. RRM2B is induced by p53 and plays a vital role in maintaining mitochondrial DNA (mtDNA) and nuclear DNA integrity, especially in non-proliferating cells. It forms an active complex with RRM1 and exhibits anti-reactive oxygen species (ROS) properties. RRM2B is essential for DNA repair, cell cycle regulation, and mitochondrial homeostasis. Mutations in the RRM2B gene are associated with mitochondrial DNA depletion syndrome (MDDS), a severe condition affecting multiple body systems, characterized by encephalomyopathy, renal tubulopathy, and mtDNA depletion. Additionally, RRM2B mutations have been linked to progressive external ophthalmoplegia and may contribute to gemcitabine resistance in certain cancers.
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技术参数
- 靶点基因名
- RRM2B
- 基因别名
- P53R2
- 蛋白别名
- ribonucleotide reductase regulatory TP53 inducible subunit M2B; RRM2B
- UniProt
- Q7LG56
- 物种
- Human
产品详情
- 靶点名称
- RRM2B
- 蛋白名称
- ribonucleotide reductase regulatory TP53 inducible subunit M2B
- 蛋白别名
- Ribonucleoside-diphosphate reductase subunit M2 B; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2
- 靶点基因名
- RRM2B
- 基因别名
- P53R2
- UniProt
- Q7LG56
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ribonucleotide reductase regulatory TP53 inducible subunit M2B (RRM2B) is a critical component of the ribonucleotide reductase enzyme, which catalyzes the conversion of ribonucleotides to deoxyribonucleotides for DNA synthesis and repair. RRM2B is induced by p53 and plays a vital role in maintaining mitochondrial DNA (mtDNA) and nuclear DNA integrity, especially in non-proliferating cells. It forms an active complex with RRM1 and exhibits anti-reactive oxygen species (ROS) properties. RRM2B is essential for DNA repair, cell cycle regulation, and mitochondrial homeostasis. Mutations in the RRM2B gene are associated with mitochondrial DNA depletion syndrome (MDDS), a severe condition affecting multiple body systems, characterized by encephalomyopathy, renal tubulopathy, and mtDNA depletion. Additionally, RRM2B mutations have been linked to progressive external ophthalmoplegia and may contribute to gemcitabine resistance in certain cancers.