抗人 RPRD1B 抗体对
01AB03389
Regulation of nuclear pre-mRNA domain containing 1B (RPRD1B), also known as CREPT, is a transcriptional regulator that modulates the activity of RNA polymerase II. It contains a specialized CTD-interacting domain (CID) that allows it to bind specific phosphorylated heptapeptide repeats on the largest subunit of the polymerase. RPRD1B acts as a positive regulator of the cell cycle by enhancing the transcription of key genes, including CCND1, CDK2, CDK4, and CDK6. Furthermore, it influences RNA polymerase II occupancy at gene termination regions and modulates the alternative polyadenylation of transcripts related to cell growth. Clinically, RPRD1B is frequently upregulated in endometrial, gastric, and colorectal cancers. In these malignancies, it promotes tumor development and rapid cell cycle progression by stabilizing tumor suppressor transcripts through 3' end processing, making it a significant marker for oncogenic proliferation.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- RPRD1B
- 基因别名
- C20orf77; CREPT
- 蛋白别名
- regulation of nuclear pre-mRNA domain containing 1B; RPRD1B
- UniProt
- Q9NQG5
- 物种
- Human
产品详情
- 靶点名称
- RPRD1B
- 蛋白名称
- regulation of nuclear pre-mRNA domain containing 1B
- 蛋白别名
- Regulation of nuclear pre-mRNA domain-containing protein 1B; Cell cycle-related and expression-elevated protein in tumor
- 靶点基因名
- RPRD1B
- 基因别名
- C20orf77; CREPT
- UniProt
- Q9NQG5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Regulation of nuclear pre-mRNA domain containing 1B (RPRD1B), also known as CREPT, is a transcriptional regulator that modulates the activity of RNA polymerase II. It contains a specialized CTD-interacting domain (CID) that allows it to bind specific phosphorylated heptapeptide repeats on the largest subunit of the polymerase. RPRD1B acts as a positive regulator of the cell cycle by enhancing the transcription of key genes, including CCND1, CDK2, CDK4, and CDK6. Furthermore, it influences RNA polymerase II occupancy at gene termination regions and modulates the alternative polyadenylation of transcripts related to cell growth. Clinically, RPRD1B is frequently upregulated in endometrial, gastric, and colorectal cancers. In these malignancies, it promotes tumor development and rapid cell cycle progression by stabilizing tumor suppressor transcripts through 3' end processing, making it a significant marker for oncogenic proliferation.