人 ROBO1 抗体对
01AB00588
Roundabout guidance receptor 1 (ROBO1) is a protein encoded by the ROBO1 gene in humans, belonging to the immunoglobulin superfamily. It functions as both an axon guidance receptor and a cell adhesion receptor, playing a crucial role in the decision by axons to cross the central nervous system midline. Structurally, ROBO1 contains multiple immunoglobulin-like (Ig) domains and fibronectin type III (Fn) repeats, which are essential for its interaction with Slit ligands to regulate midline crossing of axons. Clinically, ROBO1 has been implicated in communication disorders, such as dyslexia, and is associated with phonological memory and mathematical abilities in young children. The protein's ectodomain structure, including its Ig and Fn domains, is critical for Slit binding and repulsive signaling.
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技术参数
- 靶点基因名
- ROBO1
- 基因别名
- DUTT1
- 蛋白别名
- roundabout guidance receptor 1; ROBO1
- UniProt
- Q9Y6N7
- 物种
- Human
产品详情
- 靶点名称
- ROBO1
- 蛋白名称
- roundabout guidance receptor 1
- 蛋白别名
- Roundabout homolog 1; Deleted in U twenty twenty; H-Robo-1
- 靶点基因名
- ROBO1
- 基因别名
- DUTT1
- UniProt
- Q9Y6N7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Roundabout guidance receptor 1 (ROBO1) is a protein encoded by the ROBO1 gene in humans, belonging to the immunoglobulin superfamily. It functions as both an axon guidance receptor and a cell adhesion receptor, playing a crucial role in the decision by axons to cross the central nervous system midline. Structurally, ROBO1 contains multiple immunoglobulin-like (Ig) domains and fibronectin type III (Fn) repeats, which are essential for its interaction with Slit ligands to regulate midline crossing of axons. Clinically, ROBO1 has been implicated in communication disorders, such as dyslexia, and is associated with phonological memory and mathematical abilities in young children. The protein's ectodomain structure, including its Ig and Fn domains, is critical for Slit binding and repulsive signaling.