抗人 RNF4 抗体对
01AB00917
Ring finger protein 4 (RNF4), encoded by the gene RNF4, is an E3 ubiquitin-protein ligase characterized by a RING finger motif, which facilitates its role in protein ubiquitination and subsequent degradation. RNF4 specifically recognizes and binds to polysumoylated protein chains, targeting them for ubiquitination through Lys-6, Lys-11, Lys-48, and Lys-63 linkages, thereby regulating protein stability and turnover. This protein is critical for the elimination of misfolded proteins, such as pathogenic Atxn1 and TDP-43, and also plays a role in DNA damage response, homologous recombination, and chromosome segregation, supporting genomic stability and cellular viability. Elevated RNF4 expression is observed in several tumor types and is associated with poor survival outcomes in cancers like breast and lung adenocarcinoma, suggesting a potential oncogenic role by supporting DNA replication and tumor cell growth.
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技术参数
- 靶点基因名
- RNF4
- 基因别名
- SNURF
- 蛋白别名
- ring finger protein 4; RNF4
- UniProt
- P78317
- 物种
- Human
产品详情
- 靶点名称
- RNF4
- 蛋白名称
- ring finger protein 4
- 蛋白别名
- E3 ubiquitin-protein ligase RNF4; RING finger protein 4; Small nuclear ring finger protein; Protein SNURF
- 靶点基因名
- RNF4
- 基因别名
- SNURF
- UniProt
- P78317
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ring finger protein 4 (RNF4), encoded by the gene RNF4, is an E3 ubiquitin-protein ligase characterized by a RING finger motif, which facilitates its role in protein ubiquitination and subsequent degradation. RNF4 specifically recognizes and binds to polysumoylated protein chains, targeting them for ubiquitination through Lys-6, Lys-11, Lys-48, and Lys-63 linkages, thereby regulating protein stability and turnover. This protein is critical for the elimination of misfolded proteins, such as pathogenic Atxn1 and TDP-43, and also plays a role in DNA damage response, homologous recombination, and chromosome segregation, supporting genomic stability and cellular viability. Elevated RNF4 expression is observed in several tumor types and is associated with poor survival outcomes in cancers like breast and lung adenocarcinoma, suggesting a potential oncogenic role by supporting DNA replication and tumor cell growth.