人 RNF31 抗体对
01AB01824
E3 ubiquitin-protein ligase RNF31 (RNF31), or Ring Finger Protein 31, is an E3 ubiquitin ligase that plays a pivotal role in the ubiquitin-proteasome system, specifically within the linear ubiquitin chain assembly complex (LUBAC). This protein is essential for conjugating linear polyubiquitin chains to target substrates, thereby regulating various cellular processes, including immune signaling, inflammation, and apoptosis. RNF31 has been implicated in several diseases, particularly Immunodeficiency with Autoinflammation, where its dysfunction leads to impaired immune responses and increased susceptibility to infections. Additionally, RNF31 is associated with the progression of certain cancers, such as hepatocellular carcinoma, where it promotes cell proliferation and invasion through the activation of the NF-κB signaling pathway. This dual role highlights the importance of RNF31 in both maintaining immune homeostasis and contributing to tumorigenesis.
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技术参数
- 靶点基因名
- RNF31
- 基因别名
- ZIBRA
- 蛋白别名
- ring finger protein 31; RNF31
- UniProt
- Q96EP0
- 物种
- Human
产品详情
- 靶点名称
- RNF31
- 蛋白名称
- ring finger protein 31
- 蛋白别名
- E3 ubiquitin-protein ligase RNF31; HOIL-1-interacting protein; HOIP; RING finger protein 31; RING-type E3 ubiquitin transferase RNF31; Zinc in-between-RING-finger ubiquitin-associated domain protein
- 靶点基因名
- RNF31
- 基因别名
- ZIBRA
- UniProt
- Q96EP0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
E3 ubiquitin-protein ligase RNF31 (RNF31), or Ring Finger Protein 31, is an E3 ubiquitin ligase that plays a pivotal role in the ubiquitin-proteasome system, specifically within the linear ubiquitin chain assembly complex (LUBAC). This protein is essential for conjugating linear polyubiquitin chains to target substrates, thereby regulating various cellular processes, including immune signaling, inflammation, and apoptosis. RNF31 has been implicated in several diseases, particularly Immunodeficiency with Autoinflammation, where its dysfunction leads to impaired immune responses and increased susceptibility to infections. Additionally, RNF31 is associated with the progression of certain cancers, such as hepatocellular carcinoma, where it promotes cell proliferation and invasion through the activation of the NF-κB signaling pathway. This dual role highlights the importance of RNF31 in both maintaining immune homeostasis and contributing to tumorigenesis.