抗人 RNF168 抗体对
01AB01581
Ring finger protein 168 (RNF168) is a RING-type E3 ubiquitin ligase characterized by a core RING finger domain with a unique bent central α-helix, distinguishing it structurally from related proteins such as TRAF6, CHIP, and RNF8. RNF168 plays a crucial role in the DNA damage response, particularly in the repair of double-strand breaks (DSBs). Upon DNA damage, RNF168 is recruited to chromatin at DSB sites in an MDC1-dependent manner, where it ubiquitinates histones H2A and H2AX, thereby amplifying the DNA damage signal and facilitating the recruitment of downstream repair factors such as BRCA1 and 53BP1. This ubiquitination is essential for maintaining genome stability. Mutations in RNF168 are associated with RIDDLE syndrome, a rare disorder characterized by radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties.
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技术参数
- 靶点基因名
- RNF168
- 蛋白别名
- ring finger protein 168; RNF168
- UniProt
- Q8IYW5
- 物种
- Human
产品详情
- 靶点名称
- RNF168
- 蛋白名称
- ring finger protein 168
- 蛋白别名
- E3 ubiquitin-protein ligase RNF168; hRNF168; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168
- 靶点基因名
- RNF168
- UniProt
- Q8IYW5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ring finger protein 168 (RNF168) is a RING-type E3 ubiquitin ligase characterized by a core RING finger domain with a unique bent central α-helix, distinguishing it structurally from related proteins such as TRAF6, CHIP, and RNF8. RNF168 plays a crucial role in the DNA damage response, particularly in the repair of double-strand breaks (DSBs). Upon DNA damage, RNF168 is recruited to chromatin at DSB sites in an MDC1-dependent manner, where it ubiquitinates histones H2A and H2AX, thereby amplifying the DNA damage signal and facilitating the recruitment of downstream repair factors such as BRCA1 and 53BP1. This ubiquitination is essential for maintaining genome stability. Mutations in RNF168 are associated with RIDDLE syndrome, a rare disorder characterized by radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties.