抗人 RNF150 抗体对
01AB02761
Ring finger protein 150 (RNF150) is a member of the ring finger protein family, which are predominantly E3 ubiquitin ligases involved in tagging proteins for degradation via the ubiquitin-proteasome system, and is predicted to enable ubiquitin protein ligase activity and participate in ubiquitin-dependent protein catabolic processes. RNF150 is expressed in various human tissues, with RNA expression data indicating broad tissue distribution, including the brain, digestive tract, and reproductive organs. Functional analyses suggest RNF150 may play a role in heparin binding pathways, potentially interacting with genes such as SLIT2 and RSPO3, and is correlated with mismatch repair genes (MLH1, MSH2, MSH6, PMS2), indicating a possible involvement in genomic stability. Clinically, RNF150 expression is significantly downregulated in gastric cancer (GC) compared to normal gastric mucosa, and lower RNF150 mRNA levels are associated with better survival outcomes in GC patients.
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技术参数
- 靶点基因名
- RNF150
- 基因别名
- KIAA1214
- 蛋白别名
- ring finger protein 150; RNF150
- UniProt
- Q9ULK6
- 物种
- Human
产品详情
- 靶点名称
- RNF150
- 蛋白名称
- ring finger protein 150
- 蛋白别名
- RING finger protein 150
- 靶点基因名
- RNF150
- 基因别名
- KIAA1214
- UniProt
- Q9ULK6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ring finger protein 150 (RNF150) is a member of the ring finger protein family, which are predominantly E3 ubiquitin ligases involved in tagging proteins for degradation via the ubiquitin-proteasome system, and is predicted to enable ubiquitin protein ligase activity and participate in ubiquitin-dependent protein catabolic processes. RNF150 is expressed in various human tissues, with RNA expression data indicating broad tissue distribution, including the brain, digestive tract, and reproductive organs. Functional analyses suggest RNF150 may play a role in heparin binding pathways, potentially interacting with genes such as SLIT2 and RSPO3, and is correlated with mismatch repair genes (MLH1, MSH2, MSH6, PMS2), indicating a possible involvement in genomic stability. Clinically, RNF150 expression is significantly downregulated in gastric cancer (GC) compared to normal gastric mucosa, and lower RNF150 mRNA levels are associated with better survival outcomes in GC patients.