人 RNA Polymerase II Subunit B1 抗体对

靶点名称

RNA Polymerase II Subunit B1

蛋白名称

RNA polymerase II subunit A

蛋白别名

DNA-directed RNA polymerase II subunit RPB1; RNA polymerase II subunit B1; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase III largest subunit; RNA-directed RNA polymerase II subunit RPB1

靶点基因名

POLR2A

基因别名

POLR2

UniProt

P24928

来源物种

Homo sapiens (Human)

物种反应性

Human

背景介绍

RNA polymerase II subunit A (POLR2A) is the largest subunit of RNA polymerase II, a crucial enzyme responsible for synthesizing messenger RNA (mRNA) in eukaryotic cells. This protein plays a pivotal role in transcription regulation, facilitating the conversion of DNA into RNA, which is essential for gene expression. POLR2A is widely expressed across various tissues, including the brain, liver, and lungs, indicating its fundamental importance in cellular function and development. Mutations or dysregulation of POLR2A have been linked to several diseases, particularly cancers such as breast and lung cancer, where altered expression levels can affect tumor progression and response to therapy. Additionally, POLR2A has been implicated in neurodegenerative diseases due to its role in neuronal gene expression.