人 RICTOR 抗体对
01AB00583
RPTOR independent companion of MTOR complex 2 (RICTOR) is a protein that forms part of the mammalian target of rapamycin complex 2 (mTORC2). It plays a crucial role in integrating nutrient- and growth factor-derived signals to regulate cell growth and proliferation. Structurally, RICTOR contains few conserved regions and has 21 identified phosphorylation sites, with T1135 undergoing growth factor-responsive phosphorylation via S6K1. Functionally, RICTOR is essential for the phosphorylation of Akt/protein kinase B (PKB) on SER473, which activates Akt/PKB and is implicated in cancer and diabetes. RICTOR has been associated with various cancers, including colorectal carcinoma, glioblastoma, and pituitary adenomas, where its overexpression can lead to increased cell proliferation and survival. In embryonic development, RICTOR and mTORC2 are necessary for actin cytoskeleton organization and embryonic growth.
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技术参数
- 靶点基因名
- RICTOR
- 基因别名
- KIAA1999
- 蛋白别名
- RPTOR independent companion of MTOR complex 2; RICTOR
- UniProt
- Q6R327
- 物种
- Human
产品详情
- 靶点名称
- RICTOR
- 蛋白名称
- RPTOR independent companion of MTOR complex 2
- 蛋白别名
- Rapamycin-insensitive companion of mTOR; AVO3 homolog; hAVO3
- 靶点基因名
- RICTOR
- 基因别名
- KIAA1999
- UniProt
- Q6R327
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
RPTOR independent companion of MTOR complex 2 (RICTOR) is a protein that forms part of the mammalian target of rapamycin complex 2 (mTORC2). It plays a crucial role in integrating nutrient- and growth factor-derived signals to regulate cell growth and proliferation. Structurally, RICTOR contains few conserved regions and has 21 identified phosphorylation sites, with T1135 undergoing growth factor-responsive phosphorylation via S6K1. Functionally, RICTOR is essential for the phosphorylation of Akt/protein kinase B (PKB) on SER473, which activates Akt/PKB and is implicated in cancer and diabetes. RICTOR has been associated with various cancers, including colorectal carcinoma, glioblastoma, and pituitary adenomas, where its overexpression can lead to increased cell proliferation and survival. In embryonic development, RICTOR and mTORC2 are necessary for actin cytoskeleton organization and embryonic growth.