抗人 RIC8B 抗体对
01AB03012
RIC8 guanine nucleotide exchange factor B (RIC8B) is a cytosolic chaperone and guanine nucleotide exchange factor (GEF) for G-alpha subunits, particularly those of the Gs class. It binds nascent G-alpha proteins, facilitating their folding, biosynthesis, and transport to the plasma membrane, which is essential for functional GPCR signaling. RIC8B is particularly critical in olfactory sensory neurons for the localization of G-alpha-olf, thereby enabling odorant signal transduction. While direct links to specific human genetic syndromes are limited, its fundamental role in G-protein maintenance suggests that RIC8B dysfunction could underlie defects in sensory perception and neurotransmission.
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技术参数
- 靶点基因名
- RIC8B
- 蛋白别名
- RIC8 guanine nucleotide exchange factor B; RIC8B
- UniProt
- Q9NVN3
- 物种
- Human
产品详情
- 靶点名称
- RIC8B
- 蛋白名称
- RIC8 guanine nucleotide exchange factor B
- 蛋白别名
- Chaperone Ric-8B; Brain synembryn; hSyn; Synembryn-B
- 靶点基因名
- RIC8B
- UniProt
- Q9NVN3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
RIC8 guanine nucleotide exchange factor B (RIC8B) is a cytosolic chaperone and guanine nucleotide exchange factor (GEF) for G-alpha subunits, particularly those of the Gs class. It binds nascent G-alpha proteins, facilitating their folding, biosynthesis, and transport to the plasma membrane, which is essential for functional GPCR signaling. RIC8B is particularly critical in olfactory sensory neurons for the localization of G-alpha-olf, thereby enabling odorant signal transduction. While direct links to specific human genetic syndromes are limited, its fundamental role in G-protein maintenance suggests that RIC8B dysfunction could underlie defects in sensory perception and neurotransmission.