人 RGS9 抗体对
01AB00580
Regulator of G protein signaling 9 (RGS9), encoded by the RGS9 gene, is a GTPase-activating protein (GAP) that accelerates the deactivation of G protein-coupled receptor (GPCR) signaling by enhancing GTP hydrolysis on Gα subunits, thereby terminating downstream signals. It exists in two isoforms: RGS9-1, primarily localized in retinal photoreceptors, and RGS9-2, expressed in the striatum and other brain regions. RGS9 forms obligate complexes with the Gβ5 subunit, which stabilizes the protein, and interacts with tissue-specific partners like R9AP in the retina to regulate phototransduction. In the brain, RGS9-2 modulates dopamine and opioid receptor signaling, influencing neuronal plasticity and reward pathways. Mutations in RGS9 are linked to bradyopsia, a rare retinal disorder characterized by delayed dark adaptation and reduced light sensitivity due to impaired phototransduction kinetics.
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技术参数
- 靶点基因名
- RGS9
- 蛋白别名
- regulator of G protein signaling 9; RGS9
- UniProt
- O75916
- 物种
- Human
产品详情
- 靶点名称
- RGS9
- 蛋白名称
- regulator of G protein signaling 9
- 蛋白别名
- Regulator of G-protein signaling 9; RGS9
- 靶点基因名
- RGS9
- UniProt
- O75916
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Regulator of G protein signaling 9 (RGS9), encoded by the RGS9 gene, is a GTPase-activating protein (GAP) that accelerates the deactivation of G protein-coupled receptor (GPCR) signaling by enhancing GTP hydrolysis on Gα subunits, thereby terminating downstream signals. It exists in two isoforms: RGS9-1, primarily localized in retinal photoreceptors, and RGS9-2, expressed in the striatum and other brain regions. RGS9 forms obligate complexes with the Gβ5 subunit, which stabilizes the protein, and interacts with tissue-specific partners like R9AP in the retina to regulate phototransduction. In the brain, RGS9-2 modulates dopamine and opioid receptor signaling, influencing neuronal plasticity and reward pathways. Mutations in RGS9 are linked to bradyopsia, a rare retinal disorder characterized by delayed dark adaptation and reduced light sensitivity due to impaired phototransduction kinetics.