人 RGS8 抗体对
01AB03232
Regulator of G protein signaling 8 (RGS8) is a cytosolic GTPase-activating protein (GAP) that negatively regulates GPCR signaling by accelerating the hydrolysis of GTP on G-alpha-i/o and G-alpha-q subunits. It contains a conserved RGS domain that selectively binds activated G-alpha subunits to terminate signaling cascades downstream of receptors such as muscarinic and dopamine receptors. RGS8 is predominantly expressed in the brain, particularly the cerebellum, suggesting a role in neuronal signaling modulation. While specific monogenic diseases are not well-established, its expression patterns link it to neurological functions and potential involvement in spinocerebellar ataxia pathways.
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技术参数
- 靶点基因名
- RGS8
- 蛋白别名
- regulator of G protein signaling 8; RGS8
- UniProt
- P57771
- 物种
- Human
产品详情
- 靶点名称
- RGS8
- 蛋白名称
- regulator of G protein signaling 8
- 蛋白别名
- Regulator of G-protein signaling 8; RGS8
- 靶点基因名
- RGS8
- UniProt
- P57771
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Regulator of G protein signaling 8 (RGS8) is a cytosolic GTPase-activating protein (GAP) that negatively regulates GPCR signaling by accelerating the hydrolysis of GTP on G-alpha-i/o and G-alpha-q subunits. It contains a conserved RGS domain that selectively binds activated G-alpha subunits to terminate signaling cascades downstream of receptors such as muscarinic and dopamine receptors. RGS8 is predominantly expressed in the brain, particularly the cerebellum, suggesting a role in neuronal signaling modulation. While specific monogenic diseases are not well-established, its expression patterns link it to neurological functions and potential involvement in spinocerebellar ataxia pathways.