人 RGS21 抗体对
01AB00577
Regulator of G protein signaling 21 (RGS21) is a GTPase-activating protein (GAP) that accelerates the intrinsic GTPase activity of heterotrimeric G-protein alpha subunits (Gα), terminating G-protein-coupled receptor (GPCR) signaling. Predominantly expressed in taste buds, olfactory epithelium, and nasal mucosa, RGS21 regulates chemosensory pathways by modulating taste and odorant receptor signaling. Structurally, it contains a conserved RGS domain (residues 91-180) responsible for Gα interaction and a cysteine-rich region, with a molecular weight of ~24 kDa. Studies suggest RGS21 may influence bitter and sweet taste perception and olfactory signal transduction. Disease associations include potential roles in taste dysfunction and chronic rhinosinusitis due to its mucosal expression, and it is implicated in metabolic disorders like obesity and diabetes via altered chemosensory signaling pathways.
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技术参数
- 靶点基因名
- RGS21
- 蛋白别名
- regulator of G protein signaling 21; RGS21
- UniProt
- Q2M5E4
- 物种
- Human
产品详情
- 靶点名称
- RGS21
- 蛋白名称
- regulator of G protein signaling 21
- 蛋白别名
- Regulator of G-protein signaling 21; RGS21
- 靶点基因名
- RGS21
- UniProt
- Q2M5E4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Regulator of G protein signaling 21 (RGS21) is a GTPase-activating protein (GAP) that accelerates the intrinsic GTPase activity of heterotrimeric G-protein alpha subunits (Gα), terminating G-protein-coupled receptor (GPCR) signaling. Predominantly expressed in taste buds, olfactory epithelium, and nasal mucosa, RGS21 regulates chemosensory pathways by modulating taste and odorant receptor signaling. Structurally, it contains a conserved RGS domain (residues 91-180) responsible for Gα interaction and a cysteine-rich region, with a molecular weight of ~24 kDa. Studies suggest RGS21 may influence bitter and sweet taste perception and olfactory signal transduction. Disease associations include potential roles in taste dysfunction and chronic rhinosinusitis due to its mucosal expression, and it is implicated in metabolic disorders like obesity and diabetes via altered chemosensory signaling pathways.