人 RGS2 抗体对
01AB00574
Regulator of G-protein signaling 2 (RGS2), is a protein that functions as a GTPase-activating protein (GAP) for Gαq subunits, thereby regulating G-protein coupled receptor signaling. It is part of the RGS protein family and plays a crucial role in modulating cardiovascular functions by selectively inhibiting Gαq signaling, which is involved in vasoconstriction and hypertension. RGS2 also has protective effects against myocardial hypertrophy and atrial arrhythmias by reducing Gαq activity. In terms of disease, RGS2 deficiency has been linked to hypertension and cardiac hypertrophy, while its expression levels are associated with cancer progression, particularly in prostate cancer, where it may serve as a prognostic marker.
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技术参数
- 靶点基因名
- RGS2
- 基因别名
- G0S8
- 蛋白别名
- regulator of G protein signaling 2; RGS2
- UniProt
- P41220
- 物种
- Human
产品详情
- 靶点名称
- RGS2
- 蛋白名称
- regulator of G protein signaling 2
- 蛋白别名
- Regulator of G-protein signaling 2; RGS2; Cell growth-inhibiting gene 31 protein; G0/G1 switch regulatory protein 8
- 靶点基因名
- RGS2
- 基因别名
- G0S8
- UniProt
- P41220
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Regulator of G-protein signaling 2 (RGS2), is a protein that functions as a GTPase-activating protein (GAP) for Gαq subunits, thereby regulating G-protein coupled receptor signaling. It is part of the RGS protein family and plays a crucial role in modulating cardiovascular functions by selectively inhibiting Gαq signaling, which is involved in vasoconstriction and hypertension. RGS2 also has protective effects against myocardial hypertrophy and atrial arrhythmias by reducing Gαq activity. In terms of disease, RGS2 deficiency has been linked to hypertension and cardiac hypertrophy, while its expression levels are associated with cancer progression, particularly in prostate cancer, where it may serve as a prognostic marker.