抗人 RGS14 抗体对
01AB02021
Regulator of G protein signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates G protein, Ras/Raf–MAPK/ERK, and calcium signaling pathways. It is primarily localized in the dendritic spines of hippocampal CA2 pyramidal neurons. Structurally, RGS14 contains an RGS domain, tandem Raf-like Ras-binding domains, and a GoLoco motif, allowing it to function as both a GTPase-activating protein and a GDP-dissociation inhibitor for Gαi/o subunits. By accelerating GTP hydrolysis and stabilizing the inactive GDP-bound state, it attenuates G protein-coupled receptor signaling. Functionally, RGS14 acts as a natural suppressor of synaptic plasticity and constrains hippocampus-dependent learning and memory, serving as a critical regulator of cognitive performance and neuronal signaling dynamics.
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技术参数
- 靶点基因名
- RGS14
- 蛋白别名
- regulator of G protein signaling 14; RGS14
- UniProt
- O43566
- 物种
- Human
产品详情
- 靶点名称
- RGS14
- 蛋白名称
- regulator of G protein signaling 14
- 蛋白别名
- Regulator of G-protein signaling 14; RGS14
- 靶点基因名
- RGS14
- UniProt
- O43566
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Regulator of G protein signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates G protein, Ras/Raf–MAPK/ERK, and calcium signaling pathways. It is primarily localized in the dendritic spines of hippocampal CA2 pyramidal neurons. Structurally, RGS14 contains an RGS domain, tandem Raf-like Ras-binding domains, and a GoLoco motif, allowing it to function as both a GTPase-activating protein and a GDP-dissociation inhibitor for Gαi/o subunits. By accelerating GTP hydrolysis and stabilizing the inactive GDP-bound state, it attenuates G protein-coupled receptor signaling. Functionally, RGS14 acts as a natural suppressor of synaptic plasticity and constrains hippocampus-dependent learning and memory, serving as a critical regulator of cognitive performance and neuronal signaling dynamics.