抗人 RETN 抗体对
01AB01579
Resistin (RETN) is a cysteine-rich, secreted peptide hormone primarily expressed by immune cells such as monocytes and macrophages in humans, characterized by a unique multimeric structure with a C-terminal beta-sandwich "head" domain and an N-terminal alpha-helical "tail" segment. Functionally, resistin acts as a potent proinflammatory cytokine, stimulating the production of cytokines including IL-6, IL-1β, and TNF-α through activation of signaling pathways involving TLR4 and CAP1 receptors, and upregulating adhesion molecules in endothelial cells, thereby promoting vascular inflammation and smooth muscle cell proliferation. Beyond its inflammatory role, resistin exhibits direct antimicrobial activity by damaging bacterial membranes and modulates immune responses by recruiting and activating immune cells. Clinically, resistin has been implicated in the pathogenesis of several diseases: it is associated with insulin resistance and type 2 diabetes, and elevated levels are predictive of coronary artery disease, cardiovascular mortality, atherosclerosis, and inflammatory conditions such as arthritis.
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技术参数
- 靶点基因名
- RETN
- 基因别名
- FIZZ3; HXCP1; RSTN
- 蛋白别名
- resistin; RETN
- UniProt
- Q9HD89
- 物种
- Human
产品详情
- 靶点名称
- RETN
- 蛋白名称
- resistin
- 蛋白别名
- Resistin; Adipose tissue-specific secretory factor; ADSF; C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; Cysteine-rich secreted protein A12-alpha-like 2; Cysteine-rich secreted protein FIZZ3
- 靶点基因名
- RETN
- 基因别名
- FIZZ3; HXCP1; RSTN
- UniProt
- Q9HD89
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Resistin (RETN) is a cysteine-rich, secreted peptide hormone primarily expressed by immune cells such as monocytes and macrophages in humans, characterized by a unique multimeric structure with a C-terminal beta-sandwich "head" domain and an N-terminal alpha-helical "tail" segment. Functionally, resistin acts as a potent proinflammatory cytokine, stimulating the production of cytokines including IL-6, IL-1β, and TNF-α through activation of signaling pathways involving TLR4 and CAP1 receptors, and upregulating adhesion molecules in endothelial cells, thereby promoting vascular inflammation and smooth muscle cell proliferation. Beyond its inflammatory role, resistin exhibits direct antimicrobial activity by damaging bacterial membranes and modulates immune responses by recruiting and activating immune cells. Clinically, resistin has been implicated in the pathogenesis of several diseases: it is associated with insulin resistance and type 2 diabetes, and elevated levels are predictive of coronary artery disease, cardiovascular mortality, atherosclerosis, and inflammatory conditions such as arthritis.