抗人 Repulsive guidance molecule A 抗体对
01AB01327
Repulsive guidance molecule A (RGMA) is a glycosylphosphatidylinositol (GPI)-anchored protein that plays a significant role in neuronal development and axonal guidance, particularly in the retina. As a member of the repulsive guidance molecule family, RGMA acts as a co-receptor for bone morphogenetic proteins (BMPs), activating the SMAD signaling pathway, which is essential for various cellular processes including cell survival and differentiation. Dysregulation of RGMA has been linked to several diseases, including prostate and breast cancers, where it may inhibit tumor growth and metastasis by modulating cell adhesion and migration. Additionally, alterations in RGMA expression are associated with neurological disorders due to its role in neuronal survival and guidance.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- RGMA
- 基因别名
- RGM
- 蛋白别名
- repulsive guidance molecule BMP co-receptor a; Repulsive guidance molecule A
- UniProt
- Q96B86
- 物种
- Human
产品详情
- 靶点名称
- Repulsive guidance molecule A
- 蛋白名称
- repulsive guidance molecule BMP co-receptor a
- 蛋白别名
- Repulsive guidance molecule A; RGM domain family member A
- 靶点基因名
- RGMA
- 基因别名
- RGM
- UniProt
- Q96B86
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Repulsive guidance molecule A (RGMA) is a glycosylphosphatidylinositol (GPI)-anchored protein that plays a significant role in neuronal development and axonal guidance, particularly in the retina. As a member of the repulsive guidance molecule family, RGMA acts as a co-receptor for bone morphogenetic proteins (BMPs), activating the SMAD signaling pathway, which is essential for various cellular processes including cell survival and differentiation. Dysregulation of RGMA has been linked to several diseases, including prostate and breast cancers, where it may inhibit tumor growth and metastasis by modulating cell adhesion and migration. Additionally, alterations in RGMA expression are associated with neurological disorders due to its role in neuronal survival and guidance.