抗人 RELT 抗体对
01AB03387
RELT TNF receptor (RELT) is a type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily, characterized by its cysteine-rich extracellular domains. It is predominantly expressed in hematologic tissues, such as the spleen, lymph nodes, and peripheral blood leukocytes. RELT functions as a regulator of immune responses by costimulating T-cell proliferation in the presence of CD3 signaling. It activates the NF-kappaB signaling pathway and selectively binds to TNF receptor-associated factor 1 (TRAF1), although its activation of NF-kappaB may also proceed through TRAF-independent mechanisms. Clinically, RELT is implicated in the progression of esophageal squamous cell carcinoma, where its activation of the NF-kappaB pathway promotes tumor growth. Its presence in various leukemias and lymphomas further suggests a significant role in hematologic malignancies and the regulation of apoptotic processes within the immune system.
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技术参数
- 靶点基因名
- RELT
- 基因别名
- TNFRSF19L
- 蛋白别名
- RELT TNF receptor; RELT
- UniProt
- Q969Z4
- 物种
- Human
产品详情
- 靶点名称
- RELT
- 蛋白名称
- RELT TNF receptor
- 蛋白别名
- Tumor necrosis factor receptor superfamily member 19L; Receptor expressed in lymphoid tissues
- 靶点基因名
- RELT
- 基因别名
- TNFRSF19L
- UniProt
- Q969Z4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
RELT TNF receptor (RELT) is a type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily, characterized by its cysteine-rich extracellular domains. It is predominantly expressed in hematologic tissues, such as the spleen, lymph nodes, and peripheral blood leukocytes. RELT functions as a regulator of immune responses by costimulating T-cell proliferation in the presence of CD3 signaling. It activates the NF-kappaB signaling pathway and selectively binds to TNF receptor-associated factor 1 (TRAF1), although its activation of NF-kappaB may also proceed through TRAF-independent mechanisms. Clinically, RELT is implicated in the progression of esophageal squamous cell carcinoma, where its activation of the NF-kappaB pathway promotes tumor growth. Its presence in various leukemias and lymphomas further suggests a significant role in hematologic malignancies and the regulation of apoptotic processes within the immune system.