抗人 RASSF2 抗体对
01AB00686
Ras association domain family member 2 (RASSF2) is a potential tumor suppressor protein containing a Ras association domain. It functions as a KRAS-specific effector, promoting apoptosis and cell cycle arrest. RASSF2 interacts with K-Ras in a GTP-dependent manner and forms a complex with the prostate apoptosis response protein 4 (PAR-4) tumor suppressor. It plays a role in regulating PAR-4 nuclear translocation, which is essential for its apoptotic function. RASSF2 is primarily localized in the nucleus and is involved in protein stabilization and regulation of intracellular signal transduction. The gene is frequently epigenetically inactivated in various cancers, particularly in prostate cancer. Loss of RASSF2 expression enhances K-Ras-induced transformation and confers resistance to TRAIL-induced cell death in prostate cancer cells. RASSF2 inactivation is implicated in the early stages of colorectal tumorigenesis and may contribute to the development of other cancers.
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技术参数
- 靶点基因名
- RASSF2
- 基因别名
- CENP-34; KIAA0168
- 蛋白别名
- Ras association domain family member 2; RASSF2
- UniProt
- P50749
- 物种
- Human
产品详情
- 靶点名称
- RASSF2
- 蛋白名称
- Ras association domain family member 2
- 蛋白别名
- Ras association domain-containing protein 2
- 靶点基因名
- RASSF2
- 基因别名
- CENP-34; KIAA0168
- UniProt
- P50749
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ras association domain family member 2 (RASSF2) is a potential tumor suppressor protein containing a Ras association domain. It functions as a KRAS-specific effector, promoting apoptosis and cell cycle arrest. RASSF2 interacts with K-Ras in a GTP-dependent manner and forms a complex with the prostate apoptosis response protein 4 (PAR-4) tumor suppressor. It plays a role in regulating PAR-4 nuclear translocation, which is essential for its apoptotic function. RASSF2 is primarily localized in the nucleus and is involved in protein stabilization and regulation of intracellular signal transduction. The gene is frequently epigenetically inactivated in various cancers, particularly in prostate cancer. Loss of RASSF2 expression enhances K-Ras-induced transformation and confers resistance to TRAIL-induced cell death in prostate cancer cells. RASSF2 inactivation is implicated in the early stages of colorectal tumorigenesis and may contribute to the development of other cancers.