抗人 RASA1 抗体对
01AB01574
RAS p21 protein activator 1 (RASA1), also known as p120-RasGAP, is a cytoplasmic protein that functions as a key negative regulator of the RAS/MAPK signaling pathway, which is crucial for controlling cell proliferation, differentiation, and movement. Structurally, RASA1 contains several domains, including SH2, SH3, C2A, C2B, GAP, and PH, enabling it to interact with various signaling molecules and enhance the intrinsic GTPase activity of RAS proteins, thereby converting active RAS-GTP to its inactive GDP-bound form and suppressing RAS signaling. RASA1 is also involved in physiological processes such as angiogenesis, apoptosis, and the development of the vascular system, and its activity is regulated by intracellular calcium levels and membrane association. Pathogenic mutations or epigenetic inactivation of RASA1 are linked to vascular anomalies, such as capillary malformation-arteriovenous malformation (CM-AVM) syndrome, and have been implicated in the development of various cancers due to dysregulated RAS signaling.
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技术参数
- 靶点基因名
- RASA1
- 基因别名
- GAP; RASA
- 蛋白别名
- RAS p21 protein activator 1; RASA1
- UniProt
- P20936
- 物种
- Human
产品详情
- 靶点名称
- RASA1
- 蛋白名称
- RAS p21 protein activator 1
- 蛋白别名
- Ras GTPase-activating protein 1; GAP; GTPase-activating protein; RasGAP; Ras p21 protein activator; p120GAP
- 靶点基因名
- RASA1
- 基因别名
- GAP; RASA
- UniProt
- P20936
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
RAS p21 protein activator 1 (RASA1), also known as p120-RasGAP, is a cytoplasmic protein that functions as a key negative regulator of the RAS/MAPK signaling pathway, which is crucial for controlling cell proliferation, differentiation, and movement. Structurally, RASA1 contains several domains, including SH2, SH3, C2A, C2B, GAP, and PH, enabling it to interact with various signaling molecules and enhance the intrinsic GTPase activity of RAS proteins, thereby converting active RAS-GTP to its inactive GDP-bound form and suppressing RAS signaling. RASA1 is also involved in physiological processes such as angiogenesis, apoptosis, and the development of the vascular system, and its activity is regulated by intracellular calcium levels and membrane association. Pathogenic mutations or epigenetic inactivation of RASA1 are linked to vascular anomalies, such as capillary malformation-arteriovenous malformation (CM-AVM) syndrome, and have been implicated in the development of various cancers due to dysregulated RAS signaling.