人 RARRES1 抗体对
01AB00372
Retinoic acid receptor responder 1 (RARRES1) is a transmembrane protein encoded by the RARRES1 gene, regulated by retinoic acid receptors. Structurally, it contains an extracellular domain with adhesion motifs, a transmembrane region, and a cytoplasmic tail involved in signaling. Functionally, RARRES1 mediates cell adhesion, apoptosis, and immune regulation, potentially acting as a receptor for chemerin, a chemotactic protein implicated in inflammation and metabolism. Post-translational modifications, including glycosylation, influence its activity. RARRES1 is widely recognized as a tumor suppressor, with reduced expression linked to aggressive tumor progression and metastasis in cancers such as breast, prostate, and hepatocellular carcinoma. Additionally, it is associated with metabolic disorders, including obesity and type 2 diabetes, due to its role in adipocyte differentiation and insulin signaling. Variants in RARRES1 have also been correlated with coronary artery disease.
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技术参数
- 靶点基因名
- RARRES1
- 基因别名
- PEIG1; TIG1
- 蛋白别名
- retinoic acid receptor responder 1; RARRES1
- UniProt
- P49788
- 物种
- Human
产品详情
- 靶点名称
- RARRES1
- 蛋白名称
- retinoic acid receptor responder 1
- 蛋白别名
- Retinoic acid receptor responder protein 1; Phorbol ester-induced gene 1 protein; PERG-1; RAR-responsive protein TIG1; Tazarotene-induced gene 1 protein
- 靶点基因名
- RARRES1
- 基因别名
- PEIG1; TIG1
- UniProt
- P49788
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Retinoic acid receptor responder 1 (RARRES1) is a transmembrane protein encoded by the RARRES1 gene, regulated by retinoic acid receptors. Structurally, it contains an extracellular domain with adhesion motifs, a transmembrane region, and a cytoplasmic tail involved in signaling. Functionally, RARRES1 mediates cell adhesion, apoptosis, and immune regulation, potentially acting as a receptor for chemerin, a chemotactic protein implicated in inflammation and metabolism. Post-translational modifications, including glycosylation, influence its activity. RARRES1 is widely recognized as a tumor suppressor, with reduced expression linked to aggressive tumor progression and metastasis in cancers such as breast, prostate, and hepatocellular carcinoma. Additionally, it is associated with metabolic disorders, including obesity and type 2 diabetes, due to its role in adipocyte differentiation and insulin signaling. Variants in RARRES1 have also been correlated with coronary artery disease.