抗人 RAPGEF5 抗体对
01AB02756
Rap guanine nucleotide exchange factor 5 (RAPGEF5) is a cytoplasmic guanine nucleotide exchange factor (GEF) that activates small GTPases, including RAP1A, RAP2A, and MRAS. By promoting the exchange of GDP for GTP, it sustains the active state of these proteins within Ras-family signaling pathways. RAPGEF5 serves as a critical link between cell surface receptors and the activation of Ras/Rap, participating in downstream processes such as angiotensin-induced ERK activation and G-protein-regulated p38/JNK signaling. Through these pathways, it influences diverse cellular functions, including proliferation and differentiation. RAPGEF5 is widely expressed across human tissues, with particularly high levels observed in the brain and endocrine organs, such as the parathyroid gland, reflecting its broad role in signal transduction and cellular regulation.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- RAPGEF5
- 基因别名
- GFR; KIAA0277; MRGEF
- 蛋白别名
- Rap guanine nucleotide exchange factor 5; RAPGEF5
- UniProt
- Q92565
- 物种
- Human
产品详情
- 靶点名称
- RAPGEF5
- 蛋白名称
- Rap guanine nucleotide exchange factor 5
- 蛋白别名
- Rap guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor for Rap1; M-Ras-regulated Rap GEF; MR-GEF; Related to Epac; Repac
- 靶点基因名
- RAPGEF5
- 基因别名
- GFR; KIAA0277; MRGEF
- UniProt
- Q92565
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Rap guanine nucleotide exchange factor 5 (RAPGEF5) is a cytoplasmic guanine nucleotide exchange factor (GEF) that activates small GTPases, including RAP1A, RAP2A, and MRAS. By promoting the exchange of GDP for GTP, it sustains the active state of these proteins within Ras-family signaling pathways. RAPGEF5 serves as a critical link between cell surface receptors and the activation of Ras/Rap, participating in downstream processes such as angiotensin-induced ERK activation and G-protein-regulated p38/JNK signaling. Through these pathways, it influences diverse cellular functions, including proliferation and differentiation. RAPGEF5 is widely expressed across human tissues, with particularly high levels observed in the brain and endocrine organs, such as the parathyroid gland, reflecting its broad role in signal transduction and cellular regulation.