人 RAP1A 抗体对
01AB00371
RAP1A is a protein encoded by the RAP1A gene, belonging to the Ras-related protein family. It shares approximately 50% amino acid identity with classical RAS proteins but has distinct structural features, notably a threonine at the 61st amino acid position instead of glutamine found in RAS proteins. RAP1A counteracts the mitogenic function of RAS by competitively interacting with RAS GAPs and RAF. It plays a crucial role in integrin activation, particularly in the context of thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth. RAP1A's interaction with integrins is mediated through effectors like RAPL and RIAM, which are involved in integrin clustering and adhesion. The protein's localization to membranes where integrins are found allows it to modulate integrin affinity and clustering directly. RAP1A's role in signaling pathways underscores its importance in cellular processes and its potential involvement in diseases such as glioblastoma.
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技术参数
- 靶点基因名
- RAP1A
- 基因别名
- KREV1
- 蛋白别名
- RAP1A, member of RAS oncogene family; RAP1A
- UniProt
- P62834
- 物种
- Human
产品详情
- 靶点名称
- RAP1A
- 蛋白名称
- RAP1A, member of RAS oncogene family
- 蛋白别名
- Ras-related protein Rap-1A; C21KG; G-22K; GTP-binding protein smg p21A; Ras-related protein Krev-1
- 靶点基因名
- RAP1A
- 基因别名
- KREV1
- UniProt
- P62834
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
RAP1A is a protein encoded by the RAP1A gene, belonging to the Ras-related protein family. It shares approximately 50% amino acid identity with classical RAS proteins but has distinct structural features, notably a threonine at the 61st amino acid position instead of glutamine found in RAS proteins. RAP1A counteracts the mitogenic function of RAS by competitively interacting with RAS GAPs and RAF. It plays a crucial role in integrin activation, particularly in the context of thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth. RAP1A's interaction with integrins is mediated through effectors like RAPL and RIAM, which are involved in integrin clustering and adhesion. The protein's localization to membranes where integrins are found allows it to modulate integrin affinity and clustering directly. RAP1A's role in signaling pathways underscores its importance in cellular processes and its potential involvement in diseases such as glioblastoma.