抗人 RanGAP1 抗体对
01AB01571
Ran GTPase activating protein 1 (RANGAP1) is a 65-kDa homodimeric enzyme encoded by the RANGAP1 gene in humans, consisting of 587 amino acids. It plays a crucial role in nucleocytoplasmic transport by specifically stimulating the GTPase activity of Ran, a small GTP-binding protein, thereby facilitating the conversion of Ran-GTP to Ran-GDP. This activity is essential for the regulation of protein and RNA trafficking between the nucleus and cytoplasm, as well as for processes such as spindle assembly and mitotic cell cycle regulation. RANGAP1 acts as the immediate antagonist of RCC1, maintaining the balance of Ran's active and inactive states, and requires association with a small ubiquitin-related modifier (SUMO) for localization at the nuclear pore. Dysregulation of Ran and its associated proteins, including RANGAP1, has been implicated in various diseases, notably cancer, where altered expression levels are observed in tumor tissues.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- RANGAP1
- 基因别名
- KIAA1835; SD
- 蛋白别名
- Ran GTPase activating protein 1; RanGAP1
- UniProt
- P46060
- 物种
- Human
产品详情
- 靶点名称
- RanGAP1
- 蛋白名称
- Ran GTPase activating protein 1
- 蛋白别名
- Ran GTPase-activating protein 1; RanGAP1
- 靶点基因名
- RANGAP1
- 基因别名
- KIAA1835; SD
- UniProt
- P46060
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ran GTPase activating protein 1 (RANGAP1) is a 65-kDa homodimeric enzyme encoded by the RANGAP1 gene in humans, consisting of 587 amino acids. It plays a crucial role in nucleocytoplasmic transport by specifically stimulating the GTPase activity of Ran, a small GTP-binding protein, thereby facilitating the conversion of Ran-GTP to Ran-GDP. This activity is essential for the regulation of protein and RNA trafficking between the nucleus and cytoplasm, as well as for processes such as spindle assembly and mitotic cell cycle regulation. RANGAP1 acts as the immediate antagonist of RCC1, maintaining the balance of Ran's active and inactive states, and requires association with a small ubiquitin-related modifier (SUMO) for localization at the nuclear pore. Dysregulation of Ran and its associated proteins, including RANGAP1, has been implicated in various diseases, notably cancer, where altered expression levels are observed in tumor tissues.