人 RANBP3 抗体对
01AB00569
RAN Binding Protein 3 (RANBP3) is a nuclear protein critical for nucleocytoplasmic transport and mitotic regulation. It acts as a cofactor for XPO1/CRM1, enhancing RAN-GTP binding to exportin XPO1, thereby facilitating the nuclear export of proteins with nuclear export signals (NES). RANBP3 also interacts with RAN GTPase to regulate mitotic spindle assembly, ensuring accurate chromosome segregation. Predominantly localized in the nucleus, it exhibits molecular functions such as RAN GTPase and exportin binding. Its activity is modulated by phosphorylation during the cell cycle. In disease contexts, RANBP3 is linked to cancer, particularly colorectal and hepatocellular carcinomas. Reduced RANBP3 expression correlates with tumor metastasis and poor prognosis, implicating its role as a tumor suppressor. Dysregulation may disrupt nuclear transport and mitotic fidelity, promoting oncogenesis.
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技术参数
- 靶点基因名
- RANBP3
- 蛋白别名
- RAN binding protein 3; RANBP3
- UniProt
- Q9H6Z4
- 物种
- Human
产品详情
- 靶点名称
- RANBP3
- 蛋白名称
- RAN binding protein 3
- 蛋白别名
- Ran-binding protein 3; RanBP3
- 靶点基因名
- RANBP3
- UniProt
- Q9H6Z4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
RAN Binding Protein 3 (RANBP3) is a nuclear protein critical for nucleocytoplasmic transport and mitotic regulation. It acts as a cofactor for XPO1/CRM1, enhancing RAN-GTP binding to exportin XPO1, thereby facilitating the nuclear export of proteins with nuclear export signals (NES). RANBP3 also interacts with RAN GTPase to regulate mitotic spindle assembly, ensuring accurate chromosome segregation. Predominantly localized in the nucleus, it exhibits molecular functions such as RAN GTPase and exportin binding. Its activity is modulated by phosphorylation during the cell cycle. In disease contexts, RANBP3 is linked to cancer, particularly colorectal and hepatocellular carcinomas. Reduced RANBP3 expression correlates with tumor metastasis and poor prognosis, implicating its role as a tumor suppressor. Dysregulation may disrupt nuclear transport and mitotic fidelity, promoting oncogenesis.