抗人 RALGAPA1 抗体对
01AB01322
Ral GTPase activating protein catalytic subunit alpha 1 (RALGAPA1) is a key component of the RalGAP complex, which regulates the activity of RalA and RalB, small GTPases involved in intracellular vesicle trafficking, cell migration, and cytoskeletal dynamics. This protein exhibits GTPase activator activity, converting Ral proteins from their active GTP-bound state to an inactive GDP-bound form. RALGAPA1 functions as the catalytic subunit of the heterodimeric RalGAP complex, alongside a scaffolding β subunit, and plays a crucial role in maintaining cellular signaling balance. Dysregulation of RALGAPA1 can lead to constitutive activation of RalA, disrupting processes such as neuronal polarity and brain development. Mutations or deficiencies in RALGAPA1 are associated with profound neurodevelopmental disabilities, muscular hypotonia, infantile spasms, and feeding abnormalities. Additionally, reduced expression of RALGAPA1 has been linked to enhanced malignancy in cancers like pancreatic ductal adenocarcinoma due to increased migratory and invasive capacities of tumor cells.
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技术参数
- 靶点基因名
- RALGAPA1
- 基因别名
- GARNL1; KIAA0884; TULIP1
- 蛋白别名
- Ral GTPase activating protein catalytic subunit alpha 1; RALGAPA1
- UniProt
- Q6GYQ0
- 物种
- Human
产品详情
- 靶点名称
- RALGAPA1
- 蛋白名称
- Ral GTPase activating protein catalytic subunit alpha 1
- 蛋白别名
- Ral GTPase-activating protein subunit alpha-1; GAP-related-interacting partner to E12; GRIPE; GTPase-activating Rap/Ran-GAP domain-like 1; Tuberin-like protein 1; p240
- 靶点基因名
- RALGAPA1
- 基因别名
- GARNL1; KIAA0884; TULIP1
- UniProt
- Q6GYQ0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ral GTPase activating protein catalytic subunit alpha 1 (RALGAPA1) is a key component of the RalGAP complex, which regulates the activity of RalA and RalB, small GTPases involved in intracellular vesicle trafficking, cell migration, and cytoskeletal dynamics. This protein exhibits GTPase activator activity, converting Ral proteins from their active GTP-bound state to an inactive GDP-bound form. RALGAPA1 functions as the catalytic subunit of the heterodimeric RalGAP complex, alongside a scaffolding β subunit, and plays a crucial role in maintaining cellular signaling balance. Dysregulation of RALGAPA1 can lead to constitutive activation of RalA, disrupting processes such as neuronal polarity and brain development. Mutations or deficiencies in RALGAPA1 are associated with profound neurodevelopmental disabilities, muscular hypotonia, infantile spasms, and feeding abnormalities. Additionally, reduced expression of RALGAPA1 has been linked to enhanced malignancy in cancers like pancreatic ductal adenocarcinoma due to increased migratory and invasive capacities of tumor cells.