人 RAGE 抗体对
01AB02168
AGER, or the advanced glycosylation end-product specific receptor, plays a critical role in the relationship between aging and various diseases. This receptor, part of the immunoglobulin superfamily, interacts with advanced glycation end products (AGEs) and other ligands, triggering pro-inflammatory responses that are implicated in age-related conditions such as diabetes, cardiovascular diseases, and neurodegenerative disorders. The accumulation of AGEs in tissues is accelerated in diabetes and contributes to vascular complications, while AGER signaling is linked to the inflammatory processes that exacerbate Alzheimer's disease and other neurodegenerative conditions. Thus, AGER serves as a key mediator in the interplay between aging, inflammation, and disease progression, highlighting its potential as a therapeutic target for age-related diseases.
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技术参数
- 靶点基因名
- AGER
- 基因别名
- RAGE
- 蛋白别名
- advanced glycosylation end-product specific receptor; RAGE
- UniProt
- Q15109
- 物种
- Human
产品详情
- 靶点名称
- RAGE
- 蛋白名称
- advanced glycosylation end-product specific receptor
- 蛋白别名
- Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products
- 靶点基因名
- AGER
- 基因别名
- RAGE
- UniProt
- Q15109
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
AGER, or the advanced glycosylation end-product specific receptor, plays a critical role in the relationship between aging and various diseases. This receptor, part of the immunoglobulin superfamily, interacts with advanced glycation end products (AGEs) and other ligands, triggering pro-inflammatory responses that are implicated in age-related conditions such as diabetes, cardiovascular diseases, and neurodegenerative disorders. The accumulation of AGEs in tissues is accelerated in diabetes and contributes to vascular complications, while AGER signaling is linked to the inflammatory processes that exacerbate Alzheimer's disease and other neurodegenerative conditions. Thus, AGER serves as a key mediator in the interplay between aging, inflammation, and disease progression, highlighting its potential as a therapeutic target for age-related diseases.