人 RACGAP1 抗体对
01AB02264
Rac GTPase activating protein 1 (RACGAP1) is a cytoplasmic regulatory protein and a core component of the centralspindlin complex. In partnership with KIF23, it organizes the central spindle and controls cytokinesis by providing GTPase-activating protein (GAP) activity toward CDC42, RAC1, and RHOA. This activity is essential for modulating cortical dynamics and the formation of the myosin contractile ring during cell division. RACGAP1 is vital for embryogenesis and hematopoietic development, particularly erythropoiesis. Clinically, biallelic loss-of-function variants in RACGAP1 cause congenital dyserythropoietic anemia type IIIB, characterized by ineffective erythropoiesis and multinucleated erythroblasts. Additionally, RACGAP1 is frequently overexpressed in solid tumors, where it correlates with increased cellular proliferation and invasiveness.
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技术参数
- 靶点基因名
- RACGAP1
- 基因别名
- KIAA1478; MGCRACGAP
- 蛋白别名
- Rac GTPase activating protein 1; RACGAP1
- UniProt
- Q9H0H5
- 物种
- Human
产品详情
- 靶点名称
- RACGAP1
- 蛋白名称
- Rac GTPase activating protein 1
- 蛋白别名
- Rac GTPase-activating protein 1; Male germ cell RacGap; MgcRacGAP; Protein CYK4 homolog; CYK4; HsCYK-4
- 靶点基因名
- RACGAP1
- 基因别名
- KIAA1478; MGCRACGAP
- UniProt
- Q9H0H5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Rac GTPase activating protein 1 (RACGAP1) is a cytoplasmic regulatory protein and a core component of the centralspindlin complex. In partnership with KIF23, it organizes the central spindle and controls cytokinesis by providing GTPase-activating protein (GAP) activity toward CDC42, RAC1, and RHOA. This activity is essential for modulating cortical dynamics and the formation of the myosin contractile ring during cell division. RACGAP1 is vital for embryogenesis and hematopoietic development, particularly erythropoiesis. Clinically, biallelic loss-of-function variants in RACGAP1 cause congenital dyserythropoietic anemia type IIIB, characterized by ineffective erythropoiesis and multinucleated erythroblasts. Additionally, RACGAP1 is frequently overexpressed in solid tumors, where it correlates with increased cellular proliferation and invasiveness.