人 RABL6 抗体对
01AB02884
RAB, member RAS oncogene family like 6 (RABL6) is a cytosolic member of the Ras superfamily of small GTPases that regulates cell growth and proliferation. Acting as a proto-oncogene, it drives the G1–S phase transition by inhibiting the tumor suppressor CDKN2A and modulating the RB1 and PP2A/AKT signaling pathways. RABL6 promotes cellular survival and proliferation, with overexpression frequently observed in various malignancies, including breast cancer. While multiple splice variants exist, its primary functional role involves enhancing oncogenic signaling. Genetically, the RABL6 locus is also associated with phenotypes such as Angelman syndrome through complex genomic interactions.
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技术参数
- 靶点基因名
- RABL6
- 基因别名
- C9orf86; PARF
- 蛋白别名
- RAB, member RAS oncogene family like 6; RABL6
- UniProt
- Q3YEC7
- 物种
- Human
产品详情
- 靶点名称
- RABL6
- 蛋白名称
- RAB, member RAS oncogene family like 6
- 蛋白别名
- Rab-like protein 6; GTP-binding protein Parf; Partner of ARF; Rab-like protein 1; RBEL1
- 靶点基因名
- RABL6
- 基因别名
- C9orf86; PARF
- UniProt
- Q3YEC7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
RAB, member RAS oncogene family like 6 (RABL6) is a cytosolic member of the Ras superfamily of small GTPases that regulates cell growth and proliferation. Acting as a proto-oncogene, it drives the G1–S phase transition by inhibiting the tumor suppressor CDKN2A and modulating the RB1 and PP2A/AKT signaling pathways. RABL6 promotes cellular survival and proliferation, with overexpression frequently observed in various malignancies, including breast cancer. While multiple splice variants exist, its primary functional role involves enhancing oncogenic signaling. Genetically, the RABL6 locus is also associated with phenotypes such as Angelman syndrome through complex genomic interactions.