抗人 RAB41 抗体对
01AB02020
RAB41, member RAS oncogene family (RAB41) is a small Rab GTPase of the Ras superfamily that regulates intracellular membrane trafficking, specifically focusing on Golgi ribbon organization and ER-to-Golgi transport. Like other Rab proteins, it cycles between GDP-bound and GTP-bound states and localizes primarily to the Golgi complex and cytosol. Beyond its role in the secretory pathway, RAB41 facilitates the ESCRT-dependent repair of damaged autophagic and lysosomal membranes through interactions with VPS4A and TOM1L2, thereby maintaining autolysosomal homeostasis. This function is largely independent of its GTPase activity. Clinically, RAB41 has been linked to microvillus inclusion disease, suggesting a critical role in maintaining epithelial trafficking integrity. Its involvement in vesicle-mediated transport and protein metabolism underscores its importance in cellular stress responses and secretory pathway maintenance.
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技术参数
- 靶点基因名
- RAB41
- 蛋白别名
- RAB41, member RAS oncogene family; RAB41
- UniProt
- Q5JT25
- 物种
- Human
产品详情
- 靶点名称
- RAB41
- 蛋白名称
- RAB41, member RAS oncogene family
- 蛋白别名
- Ras-related protein Rab-41
- 靶点基因名
- RAB41
- UniProt
- Q5JT25
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
RAB41, member RAS oncogene family (RAB41) is a small Rab GTPase of the Ras superfamily that regulates intracellular membrane trafficking, specifically focusing on Golgi ribbon organization and ER-to-Golgi transport. Like other Rab proteins, it cycles between GDP-bound and GTP-bound states and localizes primarily to the Golgi complex and cytosol. Beyond its role in the secretory pathway, RAB41 facilitates the ESCRT-dependent repair of damaged autophagic and lysosomal membranes through interactions with VPS4A and TOM1L2, thereby maintaining autolysosomal homeostasis. This function is largely independent of its GTPase activity. Clinically, RAB41 has been linked to microvillus inclusion disease, suggesting a critical role in maintaining epithelial trafficking integrity. Its involvement in vesicle-mediated transport and protein metabolism underscores its importance in cellular stress responses and secretory pathway maintenance.