抗人 RAB3IL1 抗体对
01AB03383
RAB3A interacting protein like 1 (RAB3IL1) is a guanine nucleotide exchange factor (GEF) that primarily regulates Rab3A, a small GTPase essential for synaptic vesicle exocytosis. By promoting the exchange of GDP for GTP, RAB3IL1 activates Rab proteins to coordinate vesicle-mediated transport and intracellular trafficking pathways. In addition to its activity on Rab3A, the protein is suggested to modulate RAB8A and RAB8B, further extending its influence over secretory processes. RAB3IL1 also interacts with the inositol hexakisphosphate kinase InsP6K1, suggesting a link between phosphoinositide signaling and vesicle dynamics. It is widely expressed in the brain, particularly within the hippocampus and cerebral cortex, where it maintains synaptic integrity. As a key paralog of RAB3IP, RAB3IL1 serves as a critical regulator of the machinery required for neurotransmitter release and membrane trafficking.
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技术参数
- 靶点基因名
- RAB3IL1
- 蛋白别名
- RAB3A interacting protein like 1; RAB3IL1
- UniProt
- Q8TBN0
- 物种
- Human
产品详情
- 靶点名称
- RAB3IL1
- 蛋白名称
- RAB3A interacting protein like 1
- 蛋白别名
- Guanine nucleotide exchange factor for Rab-3A; Rab-3A-interacting-like protein 1; Rab3A-interacting-like protein 1; Rabin3-like 1
- 靶点基因名
- RAB3IL1
- UniProt
- Q8TBN0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
RAB3A interacting protein like 1 (RAB3IL1) is a guanine nucleotide exchange factor (GEF) that primarily regulates Rab3A, a small GTPase essential for synaptic vesicle exocytosis. By promoting the exchange of GDP for GTP, RAB3IL1 activates Rab proteins to coordinate vesicle-mediated transport and intracellular trafficking pathways. In addition to its activity on Rab3A, the protein is suggested to modulate RAB8A and RAB8B, further extending its influence over secretory processes. RAB3IL1 also interacts with the inositol hexakisphosphate kinase InsP6K1, suggesting a link between phosphoinositide signaling and vesicle dynamics. It is widely expressed in the brain, particularly within the hippocampus and cerebral cortex, where it maintains synaptic integrity. As a key paralog of RAB3IP, RAB3IL1 serves as a critical regulator of the machinery required for neurotransmitter release and membrane trafficking.