人 QPCT 抗体对
01AB00365
Glutaminyl-peptide cyclotransferase (QPCT) is an enzyme that catalyzes the intramolecular cyclization of N-terminal glutamine and glutamic acid residues into pyroglutamate residues (pGlu), a posttranslational modification known as pyroglutamylation. This process is crucial for the maturation and stability of various hormones and secretory proteins, such as gonadotropin-releasing hormone (GnRH), thyrotropin-releasing hormone (TRH), and neurotensin. QPCT is encoded by the QPCT gene and is highly expressed in the pituitary, hypothalamus, and other parts of the brain. The enzyme plays a significant role in diseases such as Alzheimer’s disease, where it contributes to the formation of pyroglutamate-modified amyloid peptides, and in cancer, where it is involved in the CD47-SIRPα pathway, affecting immune surveillance.
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技术参数
- 靶点基因名
- QPCT
- 蛋白别名
- glutaminyl-peptide cyclotransferase; QPCT
- UniProt
- Q16769
- 物种
- Human
产品详情
- 靶点名称
- QPCT
- 蛋白名称
- glutaminyl-peptide cyclotransferase
- 蛋白别名
- Glutaminyl-peptide cyclotransferase; Glutaminyl cyclase; QC; sQC; Glutaminyl-tRNA cyclotransferase; Glutamyl cyclase; EC
- 靶点基因名
- QPCT
- UniProt
- Q16769
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Glutaminyl-peptide cyclotransferase (QPCT) is an enzyme that catalyzes the intramolecular cyclization of N-terminal glutamine and glutamic acid residues into pyroglutamate residues (pGlu), a posttranslational modification known as pyroglutamylation. This process is crucial for the maturation and stability of various hormones and secretory proteins, such as gonadotropin-releasing hormone (GnRH), thyrotropin-releasing hormone (TRH), and neurotensin. QPCT is encoded by the QPCT gene and is highly expressed in the pituitary, hypothalamus, and other parts of the brain. The enzyme plays a significant role in diseases such as Alzheimer’s disease, where it contributes to the formation of pyroglutamate-modified amyloid peptides, and in cancer, where it is involved in the CD47-SIRPα pathway, affecting immune surveillance.