人 PTPRS 抗体对
01AB00566
Protein tyrosine phosphatase receptor type S (PTPRS), also known as PTPσ, is a receptor-type protein phosphatase primarily expressed in the central nervous system. It plays a crucial role in regulating various cellular processes, including synaptic plasticity and neuronal differentiation, by modulating signaling pathways through dephosphorylation of tyrosine residues on target proteins. PTPRS is characterized by its extracellular immunoglobulin-like domains and intracellular phosphatase domains, which include an active catalytic site and a regulatory domain. This protein has been implicated in several diseases, particularly Alzheimer's disease, where its genetic variants are associated with neuroprotection against early tau pathology and synaptic degeneration. Additionally, PTPRS has been linked to cholangiocarcinoma, where its expression levels correlate with patient survival outcomes.
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技术参数
- 靶点基因名
- PTPRS
- 蛋白别名
- protein tyrosine phosphatase receptor type S; PTPRS
- UniProt
- Q13332
- 物种
- Human
产品详情
- 靶点名称
- PTPRS
- 蛋白名称
- protein tyrosine phosphatase receptor type S
- 蛋白别名
- Receptor-type tyrosine-protein phosphatase S; R-PTP-S; Receptor-type tyrosine-protein phosphatase sigma; R-PTP-sigma
- 靶点基因名
- PTPRS
- UniProt
- Q13332
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Protein tyrosine phosphatase receptor type S (PTPRS), also known as PTPσ, is a receptor-type protein phosphatase primarily expressed in the central nervous system. It plays a crucial role in regulating various cellular processes, including synaptic plasticity and neuronal differentiation, by modulating signaling pathways through dephosphorylation of tyrosine residues on target proteins. PTPRS is characterized by its extracellular immunoglobulin-like domains and intracellular phosphatase domains, which include an active catalytic site and a regulatory domain. This protein has been implicated in several diseases, particularly Alzheimer's disease, where its genetic variants are associated with neuroprotection against early tau pathology and synaptic degeneration. Additionally, PTPRS has been linked to cholangiocarcinoma, where its expression levels correlate with patient survival outcomes.