人 PTPA 抗体对
01AB02263
Protein phosphatase 2 phosphatase activator (PTPA) is a highly conserved chaperone that functions as an ATP-dependent activator for the catalytic subunit of protein phosphatase 2A (PP2A). It facilitates the acquisition of substrate specificity and enzymatic activity by stabilizing the PP2A active site and modulating metal-ion coordination. PTPA is essential for proper PP2A maturation, which in turn regulates critical signaling pathways including AKT, ERK, and MAPK. Clinically, impaired PTPA function is linked to the deregulation of PP2A, contributing to malignant transformation and therapy resistance in various cancers. In the nervous system, PTPA-mediated PP2A activity is vital for preventing the hyperphosphorylation of tau and alpha-synuclein, processes central to the pathogenesis of Alzheimer’s and Parkinson’s diseases.
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技术参数
- 靶点基因名
- PTPA
- 基因别名
- PPP2R4
- 蛋白别名
- protein phosphatase 2 phosphatase activator; PTPA
- UniProt
- Q15257
- 物种
- Human
产品详情
- 靶点名称
- PTPA
- 蛋白名称
- protein phosphatase 2 phosphatase activator
- 蛋白别名
- Serine/threonine-protein phosphatase 2A activator; PP2A; subunit B'; PR53 isoform; Phosphotyrosyl phosphatase activator; PTPA; Serine/threonine-protein phosphatase 2A regulatory subunit 4; Serine/threonine-protein phosphatase 2A regulatory subunit B'
- 靶点基因名
- PTPA
- 基因别名
- PPP2R4
- UniProt
- Q15257
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Protein phosphatase 2 phosphatase activator (PTPA) is a highly conserved chaperone that functions as an ATP-dependent activator for the catalytic subunit of protein phosphatase 2A (PP2A). It facilitates the acquisition of substrate specificity and enzymatic activity by stabilizing the PP2A active site and modulating metal-ion coordination. PTPA is essential for proper PP2A maturation, which in turn regulates critical signaling pathways including AKT, ERK, and MAPK. Clinically, impaired PTPA function is linked to the deregulation of PP2A, contributing to malignant transformation and therapy resistance in various cancers. In the nervous system, PTPA-mediated PP2A activity is vital for preventing the hyperphosphorylation of tau and alpha-synuclein, processes central to the pathogenesis of Alzheimer’s and Parkinson’s diseases.