人 PTP1B 抗体对
01AB01817
Protein tyrosine phosphatase non-receptor type 1 (PTP1B) is a ubiquitously expressed cytosolic phosphatase that localizes to the endoplasmic reticulum. It serves as a critical negative regulator of signaling pathways by dephosphorylating phosphotyrosine residues on receptor tyrosine kinases, most notably the insulin and leptin receptors. By attenuating these cascades, PTP1B acts as a metabolic brake, modulating energy homeostasis and cell growth. Functional studies indicate that the inhibition of PTP1B enhances insulin sensitivity and protects against diet-induced obesity. Clinically, PTP1B is a well-established candidate gene for type 2 diabetes and obesity, making it a significant target for therapeutic intervention in metabolic disorders.
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技术参数
- 靶点基因名
- PTPN1
- 基因别名
- PTP1B
- 蛋白别名
- protein tyrosine phosphatase non-receptor type 1; PTP1B
- UniProt
- P18031
- 物种
- Human
产品详情
- 靶点名称
- PTP1B
- 蛋白名称
- protein tyrosine phosphatase non-receptor type 1
- 蛋白别名
- Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B
- 靶点基因名
- PTPN1
- 基因别名
- PTP1B
- UniProt
- P18031
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Protein tyrosine phosphatase non-receptor type 1 (PTP1B) is a ubiquitously expressed cytosolic phosphatase that localizes to the endoplasmic reticulum. It serves as a critical negative regulator of signaling pathways by dephosphorylating phosphotyrosine residues on receptor tyrosine kinases, most notably the insulin and leptin receptors. By attenuating these cascades, PTP1B acts as a metabolic brake, modulating energy homeostasis and cell growth. Functional studies indicate that the inhibition of PTP1B enhances insulin sensitivity and protects against diet-induced obesity. Clinically, PTP1B is a well-established candidate gene for type 2 diabetes and obesity, making it a significant target for therapeutic intervention in metabolic disorders.