人 PTK7 抗体对
01AB04143
Protein Tyrosine Kinase 7 (PTK7) is a pseudokinase and a member of the receptor protein tyrosine kinase family, primarily involved in modulating Wnt signaling pathways crucial for embryonic development and tissue homeostasis. Although PTK7 lacks conventional catalytic activity, it plays a significant role in cell polarity, migration, and adhesion through its interactions with various receptors, including Frizzled and LRP5/6, facilitating both canonical and non-canonical Wnt signaling. Dysregulation of PTK7 expression is implicated in several cancers, such as colon carcinoma, neuroblastoma, and hepatocellular carcinoma, often correlating with poor prognosis and metastasis. The protein's structure includes seven extracellular immunoglobulin-like domains and a transmembrane region, supporting its function as a signaling hub despite its inactive kinase domain.
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技术参数
- 靶点基因名
- PTK7
- 基因别名
- CCK4
- 蛋白别名
- protein tyrosine kinase 7 (inactive); PTK7
- UniProt
- Q13308
- 物种
- Human
产品详情
- 靶点名称
- PTK7
- 蛋白名称
- protein tyrosine kinase 7 (inactive)
- 蛋白别名
- Inactive tyrosine-protein kinase 7; Colon carcinoma kinase 4; CCK-4; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7
- 靶点基因名
- PTK7
- 基因别名
- CCK4
- UniProt
- Q13308
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Protein Tyrosine Kinase 7 (PTK7) is a pseudokinase and a member of the receptor protein tyrosine kinase family, primarily involved in modulating Wnt signaling pathways crucial for embryonic development and tissue homeostasis. Although PTK7 lacks conventional catalytic activity, it plays a significant role in cell polarity, migration, and adhesion through its interactions with various receptors, including Frizzled and LRP5/6, facilitating both canonical and non-canonical Wnt signaling. Dysregulation of PTK7 expression is implicated in several cancers, such as colon carcinoma, neuroblastoma, and hepatocellular carcinoma, often correlating with poor prognosis and metastasis. The protein's structure includes seven extracellular immunoglobulin-like domains and a transmembrane region, supporting its function as a signaling hub despite its inactive kinase domain.