人 PTGR2 抗体对
01AB01317
Prostaglandin reductase 2 (PTGR2) is an NADPH-dependent enzyme that plays a key role in the metabolism and inactivation of prostaglandins by catalyzing the reduction of the conjugated alpha,beta-unsaturated double bond of 15-keto-prostaglandins, such as 15-keto-PGE2, 15-keto-PGE1, and their alpha isomers, with highest activity toward these substrates. PTGR2 belongs to the medium-chain dehydrogenase/reductase superfamily and features a unique NADPH binding-induced conformational change in its LID motif and a polyproline type II helix, both critical for its catalytic function. Structural studies have shown that mutations in key residues like Tyr64 and Tyr259 significantly affect catalysis and substrate affinity, and that the enzyme's active site exhibits notable plasticity, especially upon inhibitor binding. Functionally, PTGR2-mediated prostaglandin inactivation is important for regulating processes such as adipocyte differentiation and insulin sensitivity, and its inhibition has been linked to potential therapeutic effects in metabolic diseases. Disease associations include evidence that silencing PTGR2 increases reactive oxygen species, suppresses pancreatic cell proliferation, and promotes cell death, suggesting a role in cancer cell survival and redox balance.
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技术参数
- 靶点基因名
- PTGR2
- 基因别名
- ZADH1
- 蛋白别名
- prostaglandin reductase 2; PTGR2
- UniProt
- Q8N8N7
- 物种
- Human
产品详情
- 靶点名称
- PTGR2
- 蛋白名称
- prostaglandin reductase 2
- 蛋白别名
- Prostaglandin reductase 2; PRG-2; 15-oxoprostaglandin 13-reductase; Zinc-binding alcohol dehydrogenase domain-containing protein 1
- 靶点基因名
- PTGR2
- 基因别名
- ZADH1
- UniProt
- Q8N8N7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Prostaglandin reductase 2 (PTGR2) is an NADPH-dependent enzyme that plays a key role in the metabolism and inactivation of prostaglandins by catalyzing the reduction of the conjugated alpha,beta-unsaturated double bond of 15-keto-prostaglandins, such as 15-keto-PGE2, 15-keto-PGE1, and their alpha isomers, with highest activity toward these substrates. PTGR2 belongs to the medium-chain dehydrogenase/reductase superfamily and features a unique NADPH binding-induced conformational change in its LID motif and a polyproline type II helix, both critical for its catalytic function. Structural studies have shown that mutations in key residues like Tyr64 and Tyr259 significantly affect catalysis and substrate affinity, and that the enzyme's active site exhibits notable plasticity, especially upon inhibitor binding. Functionally, PTGR2-mediated prostaglandin inactivation is important for regulating processes such as adipocyte differentiation and insulin sensitivity, and its inhibition has been linked to potential therapeutic effects in metabolic diseases. Disease associations include evidence that silencing PTGR2 increases reactive oxygen species, suppresses pancreatic cell proliferation, and promotes cell death, suggesting a role in cancer cell survival and redox balance.